SYNTHESIS AND BIOLOGICAL EVALUATION OF N-(SUBSTITUTED PHENYL)-2-(5H-[1,2,4]TRIAZINO[5,6-b]INDOL-3-YLSULFANYL)ACETAMIDES AS ANTIMICROBIAL, ANTIDEPRESSANT AND ANTICONVULSANT AGENTS.
N Shruthi, Boja Poojary, Vasantha Kumar, A Prathibha, Mumtaz Mohammed Hussain, B C Revanasiddappa, Himanshu Joshi
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引用次数: 0
Abstract
A new series of N-Aryl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamides were synthesized by condensation of tricyclic compound 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione with chloro N-phenylacetamides. The tricyclic compound was obtained by condensation of Isatin with thiosemicarbazide. Chloro N-phenylacetamides were obtained from different substituted anilines. Their structures were characterized by IR, 1H NMR, LC-MS and elemental analyses. Newly synthesized compounds were screened for antimicrobial, antidepressant and anticonvulsant activities. Preliminary results indicated that most of the compounds showed lesser MIC value than the standard drug used when tested for antimicrobial activity. Some of the compounds were endowed with very good antidepressant and anticonvulsant activity.
以三环化合物2,5-二氢- 3h -[1,2,4]三嗪基[5,6-b]吲哚-3-硫酮与氯- n -苯乙酰胺缩合为原料，合成了一系列n -芳基-2-(5H-[1,2,4]三嗪基[5,6-b]吲哚-3-基磺酰)乙酰胺。该三环化合物由Isatin与氨基硫脲缩合而成。从不同取代苯胺中得到氯- n -苯乙酰胺。通过IR、1H NMR、LC-MS和元素分析对其结构进行了表征。对新合成的化合物进行抗菌、抗抑郁和抗惊厥活性筛选。初步结果表明，在抗菌活性测试中，大多数化合物的MIC值低于标准药物。其中一些化合物具有很好的抗抑郁和抗惊厥活性。
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