A Case Report of Successful Treatment of Recalcitrant Childhood Localized Scleroderma with Infliximab and Leflunomide.

Q4 Medicine
Open Rheumatology Journal Pub Date : 2015-06-26 eCollection Date: 2015-01-01 DOI:10.2174/18743129014090100030
Ian D Ferguson, Peter Weiser, Kathryn S Torok
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引用次数: 25

Abstract

Herein we report successful treatment of an adolescent Caucasian female with severe progressive localized scleroderma (mixed subtype, including generalized morphea and linear scleroderma of the trunk/limb) using infliximab and leflunomide. The patient demonstrated improvement after the first 9 months of therapy based on her clinical examination, objective measures, and patient and parent global assessments. Infliximab is a potential treatment option for pediatric localized scleroderma patients who have progression of disease or who are unable to tolerate the side effect profile of more standard systemic therapy. Larger longitudinal studies or case series are needed to confirm and further investigate infliximab's role in localized scleroderma.

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英夫利昔单抗联合来氟米特治疗顽固性儿童局限性硬皮病1例。
在此,我们报告了使用英夫利昔单抗和来氟米特成功治疗了一名患有严重进行性局限性硬皮病(混合亚型,包括全身硬皮病和躯干/肢体线状硬皮病)的青春期白人女性。根据患者的临床检查、客观测量以及患者和家长的整体评估,患者在治疗的前9个月后表现出改善。英夫利昔单抗是儿童局限性硬皮病患者的潜在治疗选择,这些患者有疾病进展或无法忍受更标准的全身治疗的副作用。需要更大规模的纵向研究或病例系列来证实和进一步调查英夫利昔单抗在局限性硬皮病中的作用。
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来源期刊
Open Rheumatology Journal
Open Rheumatology Journal Medicine-Rheumatology
CiteScore
0.80
自引率
0.00%
发文量
2
期刊介绍: ENTHAM Open publishes a number of peer-reviewed, open access journals. These free-to-view online journals cover all major disciplines of science, medicine, technology and social sciences. BENTHAM Open provides researchers a platform to rapidly publish their research in a good-quality peer-reviewed journal. All peer-reviewed accepted submissions meeting high research and ethical standards are published with free access to all.
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