Low Starch/Low Dairy Diet Results in Successful Treatment of Obesity and Co-Morbidities Linked to Polycystic Ovary Syndrome (PCOS).

Journal of obesity & weight loss therapy Pub Date : 2015-04-01 DOI:10.4172/2165-7904.1000259

Jennifer L Phy, Ali M Pohlmeier, Jamie A Cooper, Phillip Watkins, Julian Spallholz, Kitty S Harris, Abbey B Berenson, Mallory Boylan

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引用次数: 46

Abstract

Background: Polycystic Ovary Syndrome (PCOS) affects approximately 15% of reproductive-age women and increases risk of insulin resistance, type 2 diabetes mellitus, cardiovascular disease, cancer and infertility. Hyperinsulinemia is believed to contribute to or worsen all of these conditions, and increases androgens in women with PCOS. Carbohydrates are the main stimulators of insulin release, but research shows that dairy products and starches elicit greater postprandial insulin secretion than non-starchy vegetables and fruits. The purpose of this study was to determine whether an 8-week low-starch/low-dairy diet results in weight loss, increased insulin sensitivity, and reduced testosterone in women with PCOS.

Methods: Prospective 8-week dietary intervention using an ad libitum low starch/low dairy diet in 24 overweight and obese women (BMI ≥ 25 kg/m² and ≤ 45 kg/m²) with PCOS. Diagnosis of PCOS was based on the Rotterdam criteria. Weight, BMI, Waist Circumference (WC), Waist-to-Height Ratio (WHtR), fasting and 2-hour glucose and insulin, homeostasis model assessment of Insulin Resistance (HOMA-IR), HbA1c, total and free testosterone, and Ferriman-Gallwey scores were measured before and after the 8-week intervention.

Results: There was a reduction in weight (-8.61 ± 2.34 kg, p<0.001), BMI (-3.25 ± 0.88 kg/m², p<0.001), WC (-8.4 ± 3.1 cm, p<0.001), WHtR (-0.05 ± 0.02 inches, p<0.001), fasting insulin (-17.0 ± 13.6 μg/mL, p<0.001) and 2-hour insulin (-82.8 ± 177.7 μg/mL, p=0.03), and HOMA-IR (-1.9 ± 1.2, p<0.001) after diet intervention. Total testosterone (-10.0 ± 17.0 ng/dL, p=0.008), free testosterone (-1.8 pg/dL, p=0.043) and Ferriman-Gallwey scores (-2.1 ± 2.7 points (p=0.001) were also reduced from pre- to post-intervention.

Conclusion: An 8-week low-starch/low-dairy diet resulted in weight loss, improved insulin sensitivity and reduced testosterone in women with PCOS.

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低淀粉/低乳制品饮食可成功治疗多囊卵巢综合征(PCOS)相关的肥胖和合并症

背景:多囊卵巢综合征(PCOS)影响约15%的育龄妇女，并增加胰岛素抵抗、2型糖尿病、心血管疾病、癌症和不孕症的风险。高胰岛素血症被认为有助于或加重所有这些情况，并增加多囊卵巢综合征妇女的雄激素。碳水化合物是胰岛素释放的主要刺激物，但研究表明，乳制品和淀粉比不含淀粉的蔬菜和水果更能促进餐后胰岛素分泌。本研究的目的是确定8周的低淀粉/低乳制品饮食是否会导致多囊卵巢综合征女性体重减轻、胰岛素敏感性增加和睾酮水平降低。方法:对24名体重超重和肥胖(BMI≥25 kg/m2和≤45 kg/m2)的多囊卵巢综合征(PCOS)妇女进行前瞻性8周饮食干预，采用随意低淀粉/低乳制品饮食。多囊卵巢综合征的诊断基于鹿特丹标准。在干预8周前后测量体重、BMI、腰围(WC)、腰高比(WHtR)、空腹和2小时血糖和胰岛素、胰岛素抵抗(HOMA-IR)稳态模型评估、HbA1c、总睾酮和游离睾酮以及Ferriman-Gallwey评分。结果:体重减轻(-8.61±2.34 kg, p2, p)。结论:8周低淀粉/低乳制品饮食可使PCOS患者体重减轻，胰岛素敏感性改善，睾酮水平降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of obesity & weight loss therapy

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