Toxicity studies of Usnea lichens containing (+/-)-usnic acid administered in feed to F344/N Nctr rats and B6C3F1/Nctr mice.

Toxicity report series Pub Date : 2022-10-01 DOI:10.22427/NTP-TOX-105

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Abstract

Usnea lichens and purified usnic acids have been used historically in traditional herbal medicine as bactericidal and antimicrobial agents. Usnea lichens contain 1%-3% (+/-)-usnic acid and extracts of these lichens are currently marketed in the United States as herbal antimicrobial agents. (+/-)-Usnic acid exhibits membrane proton uncoupling activity, which not only forms the mechanistic basis of its bactericidal action, but also has provided a rationale for its use as a fat burning, weight-loss agent. Purified (+)-usnic acid has been marketed in the United States for this purpose either alone or in combination with other chemical agents. Use of some of these fat burning products that contain (+)-usnic acid has resulted in serious liver damage. This study investigated the potential toxicity of ground Usnea lichens containing (+/-)-usnic acid in male and female Fischer 344/N Nctr rats and B6C3F1/Nctr mice that were exposed via feed for 3 months. F344/N Nctr rats were administered 0, 30, 60, 120, 360, or 720 ppm in feed, while B6C3F1/Nctr mice were administered 0, 15, 30, 60, 180, or 360 ppm in feed. (Abstract Abridged).

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F344/N Nctr 大鼠和 B6C3F1/Nctr 小鼠饲料中含有 (+/-)-usnic 酸的 Usnea 地衣的毒性研究。

Usnea 地衣和纯化的 usnic 酸在传统草药中一直被用作杀菌和抗菌剂。Usnea 地衣含有 1%-3% 的 (+/-)-usnic 酸，这些地衣的提取物目前在美国作为草药抗菌剂销售。(+/-)-鸟苷酸具有膜质子解偶联活性，这不仅是其杀菌作用的机理基础，也为其用作燃烧脂肪的减肥药提供了理论依据。纯化的(+)-麝香草酚酸已在美国市场上单独或与其他化学制剂结合使用。使用其中一些含有(+)-麝香草酸的燃脂产品会导致严重的肝损伤。本研究调查了含有(+/-)-usnic酸的磨碎乌司地衣对雌雄Fischer 344/N Nctr大鼠和B6C3F1/Nctr小鼠的潜在毒性。F344/N Nctr 大鼠的饲料用量为 0、30、60、120、360 或 720 ppm，而 B6C3F1/Nctr 小鼠的饲料用量为 0、15、30、60、180 或 360 ppm。(摘要有删节）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Toxicity report series

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