Incidence of mandibular osteoradionecrosis (MORN) after intensity modulated radiotherapy (IMRT) versus 3D conformal radiotherapy (3D-CRT): A systematic review.

IF 2.2 3区医学

Medicina oral, patologia oral y cirugia bucal Pub Date : 2022-11-01 DOI:10.4317/medoral.25459

C-A Céspedes-Ajún, S Amghar-Maach, C Gay-Escoda

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引用次数: 2

Abstract

Background: Analyze the incidence of MORN after head and neck radiotherapy by two novel irradiation techniques, 3DCRT and IMRT and compare the success rates of distinct authors.

Material and methods: An electronic search in Pubmed (MEDLINE), Ovid, Google Scholar and Cochrane Library (Wiley), databases was conducted with the key words "Radiotherapy, Conformal"[Mesh] OR "Radiotherapy, Intensity-Modulated"[Mesh]) AND "Osteoradionecrosis"[Mesh] for all databases. The inclusion criteria randomized controlled trials (RCT), as well as prospective and retrospective cohort studies published in English; MORN patients treated with 3D-CRT y IMRT.

Results: 27 articles were selected from 194 initially found. 14 articles out of 27 were excluded and finally included 8 publications were included in the systematic review that were ranked according to their level of scientific evidence using the SORT criteria.

Conclusions: When both RT techniques were compared; IMRT revealed a lower risk incidence of MORN development and enhanced dose constraint than 3D-CRT (less than 10%), this improvement could translate into less complications post RT treatment.

Abstract Image

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强度调制放疗(IMRT)与三维适形放疗(3D- crt)后下颌骨放射性坏死(MORN)的发生率:一项系统综述。

背景:分析3DCRT和IMRT两种新型放疗技术头颈部放疗后MORN的发生率，并比较不同作者的成功率。材料和方法:电子检索Pubmed (MEDLINE)、Ovid、Google Scholar和Cochrane Library (Wiley)数据库，检索关键词为“radiation, Conformal”[Mesh]或“radiation, Intensity-Modulated”[Mesh]和“osteradionecrosis”[Mesh]。纳入标准为随机对照试验(RCT)，以及以英文发表的前瞻性和回顾性队列研究;3D-CRT + IMRT治疗MORN患者。结果:从最初发现的194篇文章中筛选出27篇。27篇文章中有14篇被排除，最终纳入8篇论文被纳入系统评价，根据其科学证据水平使用SORT标准进行排名。结论:当两种RT技术比较时;与3D-CRT相比，IMRT显示MORN发生的风险发生率较低，剂量约束增强(小于10%)，这种改善可以转化为RT治疗后并发症较少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina oral, patologia oral y cirugia bucal Medicine-Surgery

CiteScore

4.50

自引率

0.00%

发文量

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology