Efficacy of non-surgical periodontal treatment on patients with coronary artery disease: a meta-analysis of randomized controlled trials.

IF 2.2 3区 医学
C Liu, F Shi, W Li, J Chen
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引用次数: 1

Abstract

Background: Coronary artery disease (CAD) is defined as one of the most common cardiovascular diseases (CVDs). Periodontitis is one of the risk factors for CAD.

Material and methods: PubMed, Embase and Cochrane Library databases were carefully and thoroughly retrieved until October 2021. On the basis of the inclusion and exclusion criteria, eligible articles were selected strictly to identify randomized controlled trials (RCTs). Using Cochran's Q statistic, Review Manager 5.4 and Stata 16, data were extracted, and a comprehensive analysis was carried out.

Results: Six RCTs of 619 patients were included in this study, including 360 in the intervention group (IG) and 259 in the control group (CG). Meta-analysis showed significant difference for C-reactive protein (CRP) (1.20mg/L, 95% CI: 1.13 to 1.27, p < 0.00001) after non-surgical periodontal therapy (NSPT), but showed no significant difference for interleukin-6 (IL-6) (1.19mg/L, 95% CI: -1.03 to 3.40, p=0.29), flow-mediated dilation (FMD) (-1.64%, 95% CI: -4.95 to 1.67, p=0.33), triacylglycerol (TG) (-0.02mg/dL, 95% CI: -0.31 to 0.27, p=0.90), total cholesterol (TC) (0.04mg/dL, 95% CI: -0.25 to 0.33, p=0.90), low-density lipoprotein cholesterol (LDL-C) (0.00mg/dL, 95% CI: -0.29 to 0.29, p=0.99) and high-density lipoprotein cholesterol (HDL-C) (0.11mg/dL, 95% CI: -0.18 to 0.40, p=0.46).

Conclusions: The impact of NSPT on the reduction of CRP in patients of CAD with periodontitis is significant. NSPT can be considered as an important preventive strategy for major cardiovascular events in CAD.

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非手术牙周治疗对冠状动脉疾病患者的疗效:一项随机对照试验的荟萃分析。
背景:冠状动脉疾病(CAD)被定义为最常见的心血管疾病(CVD)之一。牙周炎是CAD的风险因素之一。材料和方法:PubMed、Embase和Cochrane Library数据库被仔细彻底检索,直到2021年10月。根据纳入和排除标准,严格选择符合条件的文章,以确定随机对照试验(RCT)。使用Cochran的Q统计量、Review Manager 5.4和Stata 16提取数据,并进行综合分析。结果:本研究纳入619名患者的6项随机对照试验,其中干预组360例,对照组259例。荟萃分析显示,非手术牙周治疗(NSPT)后C反应蛋白(CRP)(1.20mg/L,95%CI:1.13至1.27,p<0.00001)存在显著差异,但白细胞介素-6(IL-6)(1.19mg/L,95%CI=1.03至3.40,p=0.29)、流介导扩张(FMD)(-1.64%,95%CI-4.95至1.67,p=0.33)无显著差异,三酰甘油(TG)(-0.02mg/dL,95%CI:-0.31-0.27,p=0.90)、总胆固醇(TC)(0.04mg/dL,95%可信区间:-0.25-0.33,p=0.90),低密度脂蛋白胆固醇(LDL-C)(0.00mg/dL,95%CI:0.29-0.29,p=0.99)和高密度脂蛋白蛋白胆固醇(HDL-C)(0.11mg/d L,95%CI-0.18-0.40,p=0.46)。NSPT可以被认为是CAD中主要心血管事件的重要预防策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
52
期刊介绍: 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology
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