Mechanisms of promoting the differentiation and bone resorption function of osteoclasts by Staphylococcus aureus infection

IF 4.5 3区医学 Q1 MICROBIOLOGY

International Journal of Medical Microbiology Pub Date : 2022-10-01 DOI:10.1016/j.ijmm.2022.151568

Zelei Tong , Zhihao Chen , Ziyuan Li , Zonggang Xie , Haifang Zhang

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引用次数: 4

Abstract

Bone infection is a common and serious complication in the field of orthopedics, which frequently leads to excessive bone destruction and fracture nonunion. Staphylococcus aureus (S. aureus) infection affects bone cell function which, in turn, causes bone destruction. Bone is mainly regulated by osteoblasts and osteoclasts. Osteoclasts are the only cell type with bone resorptive function. Their over-activation is closely associated with excessive bone loss. Understanding how S. aureus changes the functional state of osteoclasts is the key to effective treatment. By reviewing the literature, this paper summarizes several mechanisms of bone destruction caused by S. aureus influencing osteoclasts, thereby stimulating new ideas for the treatment of bone infection.

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金黄色葡萄球菌感染促进破骨细胞分化及骨吸收功能的机制

骨感染是骨科领域常见且严重的并发症，常导致骨过度破坏和骨折不愈合。金黄色葡萄球菌(金黄色葡萄球菌)感染影响骨细胞功能，进而导致骨破坏。骨主要受成骨细胞和破骨细胞的调控。破骨细胞是唯一具有骨吸收功能的细胞类型。它们的过度激活与骨质过度流失密切相关。了解金黄色葡萄球菌如何改变破骨细胞的功能状态是有效治疗的关键。本文通过对文献的梳理，总结金黄色葡萄球菌影响破骨细胞导致骨破坏的几种机制，从而为骨感染的治疗提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Medical Microbiology 医学-病毒学

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

45 days

期刊介绍： Pathogen genome sequencing projects have provided a wealth of data that need to be set in context to pathogenicity and the outcome of infections. In addition, the interplay between a pathogen and its host cell has become increasingly important to understand and interfere with diseases caused by microbial pathogens. IJMM meets these needs by focussing on genome and proteome analyses, studies dealing with the molecular mechanisms of pathogenicity and the evolution of pathogenic agents, the interactions between pathogens and host cells ("cellular microbiology"), and molecular epidemiology. To help the reader keeping up with the rapidly evolving new findings in the field of medical microbiology, IJMM publishes original articles, case studies and topical, state-of-the-art mini-reviews in a well balanced fashion. All articles are strictly peer-reviewed. Important topics are reinforced by 2 special issues per year dedicated to a particular theme. Finally, at irregular intervals, current opinions on recent or future developments in medical microbiology are presented in an editorial section.