Exosomes as diagnostic tools.

2区医学 Q1 Chemistry

Advances in Clinical Chemistry Pub Date : 2022-01-01 Epub Date: 2022-08-31 DOI:10.1016/bs.acc.2022.06.004

Shweta Gupta, P B Mazumder

引用次数: 2

Abstract

Exosomes have evolved into novel candidates as diagnostic tools due to their composition of proteins and nucleic acids and ability to cross hypoxic regions, the systemic circulation and blood vessel barriers. Exosomes are nano-sized extracellular vesicles that contain information from their source cells and are found in almost all body fluids. In this chapter, we have focused on basic biogenesis, contents, and functions of these unique particles, and provide a comprehensive discussion on their usefulness as novel diagnostic tools in various diseases. In addition, these unique features make them potential candidates for development of advanced therapeutics and monitoring thereof.

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外泌体作为诊断工具。

外泌体由于其蛋白质和核酸的组成以及穿越缺氧区、体循环和血管屏障的能力，已经发展成为新的候选诊断工具。外泌体是纳米级的细胞外囊泡，包含来自其源细胞的信息，几乎存在于所有体液中。在本章中，我们重点介绍了这些独特颗粒的基本生物发生，内容和功能，并全面讨论了它们作为各种疾病的新诊断工具的用途。此外，这些独特的特征使它们成为开发先进疗法及其监测的潜在候选者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Clinical Chemistry 医学-医学实验技术

CiteScore

10.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Clinical Chemistry volumes contain material by leading experts in academia and clinical laboratory science. The reviews cover a wide variety of clinical chemistry disciplines including clinical biomarker exploration, cutting edge microarray technology, proteomics and genomics. It is an indispensable resource and practical guide for practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general.