Joan Kim, Seung Woo Choi, Young Shin Lee, Jung Myung Lee, Hyemoon Chung, Jong Shin Woo, Woo-Shik Kim, Yun Young Choi, Weon Kim
{"title":"Correlations Between Coronary Artery Disease, Coronary Artery Calcium Score, and Lipoprotein(a) Level in Korea.","authors":"Joan Kim, Seung Woo Choi, Young Shin Lee, Jung Myung Lee, Hyemoon Chung, Jong Shin Woo, Woo-Shik Kim, Yun Young Choi, Weon Kim","doi":"10.2147/TCRM.S374372","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Lipoprotein(a) (Lp(a)) levels are associated with coronary artery disease (CAD) and aortic valve calcification. This study aimed to determine the correlation between Lp(a) levels and coronary artery calcium (CAC) scores in patients who underwent coronary computed tomography angiography (CCTA).</p><p><strong>Methods: </strong>This was a single-center observational study. The patients had not been previously diagnosed with CAD and underwent CCTA and Lp(a) measurement in a three-month timeframe. Coronary angiography and further management were performed according to the physician's decision. Of the 252 patients, 81 and 171 patients underwent coronary revascularization and received medical treatment only, respectively. To examine the relationship between Lp(a) and CAC score and between Lp(a) and CAD, we divided the patients by Lp(a) level (50 mg/dL) and CAC score (400).</p><p><strong>Results: </strong>No relationship was observed between Lp(a) and CAD or other risk factors for CAD. There were no differences in the ratio of patients who underwent coronary revascularization or in the CAC score according to an Lp(a) level of 50 mg/dL. There was no difference in Lp(a) level at a CAC score of 400. The proportion of patients who underwent coronary revascularization was high in the high CAC score group (50.6% vs 23.7%, p = 0.000). No association was observed between Lp(a) level and CAC score in the Spearman correlation (0.000, p < 0.998).</p><p><strong>Conclusion: </strong>Correlations between Lp(a) level and CAC score and between Lp(a) and CAD were not observed in this Korean cohort study. However, a high CAC score was correlated with coronary revascularization.</p>","PeriodicalId":22977,"journal":{"name":"Therapeutics and Clinical Risk Management","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/37/tcrm-18-981.PMC9533785.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutics and Clinical Risk Management","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/TCRM.S374372","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Lipoprotein(a) (Lp(a)) levels are associated with coronary artery disease (CAD) and aortic valve calcification. This study aimed to determine the correlation between Lp(a) levels and coronary artery calcium (CAC) scores in patients who underwent coronary computed tomography angiography (CCTA).
Methods: This was a single-center observational study. The patients had not been previously diagnosed with CAD and underwent CCTA and Lp(a) measurement in a three-month timeframe. Coronary angiography and further management were performed according to the physician's decision. Of the 252 patients, 81 and 171 patients underwent coronary revascularization and received medical treatment only, respectively. To examine the relationship between Lp(a) and CAC score and between Lp(a) and CAD, we divided the patients by Lp(a) level (50 mg/dL) and CAC score (400).
Results: No relationship was observed between Lp(a) and CAD or other risk factors for CAD. There were no differences in the ratio of patients who underwent coronary revascularization or in the CAC score according to an Lp(a) level of 50 mg/dL. There was no difference in Lp(a) level at a CAC score of 400. The proportion of patients who underwent coronary revascularization was high in the high CAC score group (50.6% vs 23.7%, p = 0.000). No association was observed between Lp(a) level and CAC score in the Spearman correlation (0.000, p < 0.998).
Conclusion: Correlations between Lp(a) level and CAC score and between Lp(a) and CAD were not observed in this Korean cohort study. However, a high CAC score was correlated with coronary revascularization.
背景:脂蛋白(Lp(a))水平与冠状动脉疾病(CAD)和主动脉瓣钙化有关。本研究旨在确定接受冠状动脉计算机断层血管造影(CCTA)的患者Lp(a)水平与冠状动脉钙(CAC)评分之间的相关性。方法:本研究为单中心观察性研究。患者之前未被诊断为CAD，并在三个月的时间内接受了CCTA和Lp(a)测量。根据医生的决定进行冠状动脉造影和进一步的处理。在252名患者中，分别有81名和171名患者接受了冠状动脉血管重建术和仅接受了药物治疗。为了研究Lp(a)与CAC评分之间的关系以及Lp(a)与CAD之间的关系，我们将患者按Lp(a)水平(50 mg/dL)和CAC评分(400)进行分组。结果:Lp(a)与冠心病及其他危险因素无相关性。在接受冠状动脉血运重建术的患者比例或根据Lp(a)水平为50 mg/dL的CAC评分方面没有差异。在CAC评分为400分时，Lp(a)水平无差异。高CAC评分组接受冠状动脉血运重建术的患者比例较高(50.6% vs 23.7%， p = 0.000)。在Spearman相关中，Lp(a)水平与CAC评分无相关性(0.000,p < 0.998)。结论:在这项韩国队列研究中，未观察到Lp(a)水平与CAC评分以及Lp(a)与CAD之间的相关性。然而，高CAC评分与冠状动脉血运重建术相关。
期刊介绍：
Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas.
The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature.
As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication.
The journal does not accept study protocols, animal-based or cell line-based studies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
