Abnormality of Contingent Negative Variation Correlates with Parkinson's Disease Severity.

Q3 Medicine

Innovations in clinical neuroscience Pub Date : 2022-07-01

Plamen Tzvetanov, Ivan Lisichkov, Rossen T Rousseff, Vishwajit Hegde, Sergey Kostadinov

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Abstract

Objective: We sought to assess the influence of Parkinson's disease (PD) on contingent negative variation (CNV).

Patients and methods: This prospective study included 49 patients with PD (69.7±16.5; 35 male) and 35 age- and sex-matched controls. The PD cohort was subdivided, according to the Hoehn-Yahr Scale, Unified Parkinson's Disease Rating Scale (UPDRS), and UPDRS Part III, into 30 cases of uncomplicated PD and 19 cases of advanced PD. CNV was recorded over the frontal and central vertex with a linked bimastoid reference using a dual-stimulus paradigm with interstimulus intervals (ISIs) of 1.7 and 2.0 seconds.

Results: In advanced PD, the amplitude of the late CNV over the central vertex was markedly reduced (p<0.005) at ISI of 1.7 seconds and correlated negatively with UPDRS (r=-0.32; p<0.003) and motor score (UPDRS Part III) (r=-0.45; p<0.002).

Conclusion: Late CNV amplitude was significantly abnormal in PD and correlated with the severity of the motor manifestations.

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偶然负变异异常与帕金森病严重程度相关

目的:我们试图评估帕金森病(PD)对偶然负变异(CNV)的影响。患者和方法:本前瞻性研究纳入49例PD患者(69.7±16.5;35名男性)和35名年龄和性别匹配的对照组。根据Hoehn-Yahr量表、统一帕金森病评定量表(UPDRS)和UPDRS第三部分，PD队列被细分为30例无并发症PD和19例晚期PD。采用双刺激模式，在刺激间隔(ISIs)分别为1.7秒和2.0秒的情况下，记录前额顶点和中央顶点的CNV。结果:PD中晚期CNV幅值明显降低(ppp)。结论:PD中晚期CNV幅值明显异常，且与运动表现的严重程度相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Innovations in clinical neuroscience Medicine-Psychiatry and Mental Health

CiteScore

2.10

自引率

0.00%

发文量