Pre-, Peri-, and Neonatal Factors Associated with Autism Spectrum Disorder: Results of a Lebanese Case-control Study.

Q3 Medicine
Innovations in clinical neuroscience Pub Date : 2022-07-01
Aline Hajj, Souheil Hallit, Rouba El-Khatib, Sandra Abi Haidar, Fabienne Hajj Moussa Lteif, Layal Hajj, Maguy Moudawar, Lydia Rabbaa Khabbaz
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Abstract

Objective: The prevalence of autism spectrum disorder (ASD) in Lebanon is higher than what is reported by the World Health Organization (WHO), leading to the thought that the Lebanese population has some specific risk factors for ASD. Therefore, it is important to conduct more robust studies on this population. We conducted this study to identify pre-, peri-, and neonatal risk factors for ASD. Our ultimate goal was to detect and change some modifiable risk factors, thus reducing the incidence of ASD.

Design: A case-control study was conducted using a random proportional sample of Lebanese children with ASD to explore whether risk factors, such as family history, pregnancy (including all medication and substances taken during pregnancy and infection history), gestational age, delivery, birth milestones, and the neonate's condition at birth could be associated with a higher prevalence of ASD. The local ethical committee approved the study (USJ-2016-91), and all parents gave their written consent.

Results: A total of 66 children with ASD and 66 controls were included. The results of the multivariable analysis showed that a higher gestational weight gain (adjusted odds ratio [ORa]: 1.11) was significantly associated with higher odds of autism, whereas female sex (ORa: 0.13) and higher number of weeks of gestation (ORa: 0.76) were significantly associated with lower odds of autism.

Conclusion: Such results are of great relevance, since many of the identified factors herein could be avoidable or modifiable, suggesting the need for implementing timely and appropriate public health strategies for disease prevention in pregnant women that could reduce ASD.

与自闭症谱系障碍相关的产前、围生期和新生儿因素:黎巴嫩病例对照研究的结果。
目的:黎巴嫩的自闭症谱系障碍(ASD)患病率高于世界卫生组织(WHO)的报告,导致人们认为黎巴嫩人口具有某些特定的ASD危险因素。因此,对这一人群进行更有力的研究是很重要的。我们进行这项研究是为了确定ASD的前、中、新生儿危险因素。我们的最终目标是发现并改变一些可改变的危险因素,从而降低ASD的发病率。设计:采用随机比例抽样的黎巴嫩ASD儿童进行病例对照研究,探讨家族史、妊娠(包括妊娠期间服用的所有药物和物质以及感染史)、胎龄、分娩、出生里程碑和新生儿出生时的状况等危险因素是否与ASD的高患病率相关。当地伦理委员会批准了这项研究(USJ-2016-91),所有家长都给予了书面同意。结果:共纳入66例ASD患儿和66例对照组。多变量分析结果显示,较高的妊娠期体重增加(调整比值比[ORa]: 1.11)与较高的自闭症几率显著相关,而女性(调整比值比:0.13)和较高的妊娠周数(调整比值比:0.76)与较低的自闭症几率显著相关。结论:这些结果具有重要的相关性,因为许多确定的因素是可以避免或改变的,提示需要及时和适当的公共卫生策略来预防孕妇疾病,以减少ASD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Innovations in clinical neuroscience
Innovations in clinical neuroscience Medicine-Psychiatry and Mental Health
CiteScore
2.10
自引率
0.00%
发文量
87
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