Antioxidant Supplementation on Sperm DNA Fragmentation and Sperm Parameters: A Systematic Review and Meta-Analysis.

IF 1 Q4 UROLOGY & NEPHROLOGY

Turkish journal of urology Pub Date : 2022-09-01 DOI:10.5152/tud.2022.22058

Bambang Sasongko Noegroho, Safendra Siregar, Kevin Anthony Glorius Tampubolon

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引用次数: 3

Abstract

Objective: Infertility affects about 15% of couples in reproductive age worldwide. Male factors are the main causes for this condition. Antioxidants have long been used for infertility treatment as they are easily available with a low cost. In this systematic review, we focused on the relation between antioxidant supplementation and sperm DNA fragmentation and other sperm parameters.

Material and methods: An online search from PubMed and ScienceDirect databases was conducted by 2 reviewers. We reviewed full-text articles to obtain detailed information.

Results: Nine articles were included in this study. Four studies revealed a statistically significant reduction of sperm DNA fragmentation and five studies revealed an insignificant decrease of sperm DNA fragmentation. Sperm concentration, sperm motility, and morphology were also increased after antioxidant supplementation. Pregnancy rates were reported in 3 studies; the rates increased in 2 studies, and similar rate to placebo group was observed in 1 study.

Conclusion: Antioxidant supplementation can counteract against oxidative stress and improve spermatogenesis process reflected by decrease of DNA Fragmentation Index (DFI), improvement of sperm parameters, and elevation of pregnancy rates confirmed by those included studies.

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补充抗氧化剂对精子DNA碎片和精子参数的影响:系统综述和荟萃分析。

目的:全世界约15%的育龄夫妇患有不孕症。男性因素是导致这种情况的主要原因。抗氧化剂长期以来一直用于治疗不孕症，因为它们容易获得，成本低。在这篇系统综述中，我们重点研究了抗氧化剂补充与精子DNA断裂和其他精子参数的关系。材料和方法:由2名审稿人从PubMed和ScienceDirect数据库中进行在线检索。我们查阅了全文文章以获得详细信息。结果:本研究共纳入9篇文章。四项研究显示精子DNA碎片的减少具有统计学意义，五项研究显示精子DNA碎片的减少不显著。补充抗氧化剂后，精子浓度、精子活力和形态均有所增加。3项研究报告了妊娠率;2项研究的发生率升高，1项研究的发生率与安慰剂组相似。结论:本研究证实，补充抗氧化剂可抑制氧化应激，改善精子发生过程，降低DNA碎片指数(DFI)，改善精子参数，提高妊娠率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish journal of urology Medicine-Urology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The aim of the Turkish Journal of Urology is to contribute to the literature by publishing scientifically high-quality research articles as well as reviews, editorials, letters to the editor and case reports. The journal’s target audience includes, urology specialists, medical specialty fellows and other specialists and practitioners who are interested in the field of urology.