The effect of metastasis location on outcome after cytoreductive surgery and heated intraperitoneal chemotherapy.

IF 1.4 Q4 ONCOLOGY

Pleura and Peritoneum Pub Date : 2022-05-23 eCollection Date: 2022-09-01 DOI:10.1515/pp-2022-0106

Lise Hommelgaard, Jonas A Funder, Victor J Verwaal

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Abstract

Objectives: This study aims to evaluate how metastases in the seven topographical regions of the simplified peritoneal cancer index (sPCI) affect the survival of patients treated with cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis (PC) from colorectal (CRC) or appendiceal cancers.

Methods: Data was collected retrospectively from patient records. Abdominal regions affected by PC were identified using the histological verification of surgically removed tumours found in the electronic pathology report. Verified tumours were grouped according to the sPCI topography.

Results: One hundred and eighty-three patients treated with CRS and HIPEC were included. Metastases in the small bowel had a negative impact on survival with a hazard ratio of 1.89 (p=0.005). A significantly impaired survival was also detected for patients affected by metastases in the ileocolic region (p=0.01) and in the omentum and spleen (p=0.04).

Conclusions: When selecting patients for CRS and HIPEC a more cautious approach may be applied by considering the regions affected.

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转移部位对细胞减缩手术及腹腔热化疗后预后的影响。

目的:本研究旨在评估简化腹膜癌指数(sPCI)的七个地形区域的转移如何影响结肠直肠癌(CRC)或阑尾癌腹膜癌(PC)患者接受细胞减缩手术(CRS)和腹腔加热化疗(HIPEC)治疗的生存。方法:回顾性收集病例资料。通过电子病理报告中发现的手术切除肿瘤的组织学验证，确定了受PC影响的腹部区域。根据sPCI地形对确诊肿瘤进行分组。结果:纳入CRS和HIPEC治疗的患者183例。小肠转移对生存有负面影响，风险比为1.89 (p=0.005)。在回肠结肠区(p=0.01)和网膜和脾脏(p=0.04)转移的患者的生存期也明显受损。结论:在选择CRS和HIPEC患者时，应考虑受影响的区域，采取更为谨慎的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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