[Statins and influenza mortality: systematic review and meta-analysis].

IF 0.4 4区医学 Q4 INFECTIOUS DISEASES

Revista Chilena De Infectologia Pub Date : 2022-06-01 DOI:10.4067/s0716-10182022000200321

Walter Masson, Martin Lobo, Augusto Lavalle-Cobo, Gerardo Masson, Graciela Molinero, Melina Huerín

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引用次数: 0

Abstract

Background: Due to their anti-inflammatory properties, it has been suggested that the use of statins could influence the evolution of influenza virus infection.

Aim: To evaluate the effect of statin therapy on mortality from influenza.

Methods: A meta-analysis that included studies evaluating the use of statins in patients with influenza and reporting data on mortality, after searching the PubMed/MEDLINE, Embase, and Cochrane Controlled Trials databases, was performed. A random effects model was applied. The risk of bias was analyzed and a sensitivity analysis was performed.

Results: Eight studies (10 independent cohorts), which included a total of 2,390,730 patients, were identified and eligible for analysis. A total of 1,146,995 subjects analyzed received statins, while 1,243,735 subjects were part of the control group. Statin therapy was associated with lower mortality (OR: 0.66; 95% CI: 0.51-0.85). The sensitivity analysis showed that the results were robust.

Conclusion: Our data suggest that, in a population with influenza, the use of statins was associated with a significant reduction in mortality. These results must be confirmed in future clinical trials.

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[他汀类药物和流感死亡率:系统回顾和荟萃分析]。

背景:由于他汀类药物的抗炎特性，有人认为他汀类药物的使用可能会影响流感病毒感染的演变。目的:评价他汀类药物治疗对流行性感冒死亡率的影响。方法:在检索PubMed/MEDLINE、Embase和Cochrane对照试验数据库后，进行荟萃分析，包括评估他汀类药物在流感患者中的使用和报告死亡率数据的研究。采用随机效应模型。对偏倚风险进行分析，并进行敏感性分析。结果:8项研究(10个独立队列)共纳入2,390,730例患者，符合分析条件。共有1,146,995名受试者接受了他汀类药物治疗，而对照组为1,243,735名受试者。他汀类药物治疗与较低的死亡率相关(OR: 0.66;95% ci: 0.51-0.85)。敏感性分析表明，结果是稳健的。结论:我们的数据表明，在流感人群中，他汀类药物的使用与死亡率的显著降低有关。这些结果必须在未来的临床试验中得到证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Chilena De Infectologia 医学-传染病学

CiteScore

0.90

自引率

20.00%

发文量

审稿时长

4-8 weeks

期刊介绍： La Revista Chilena de Infectología publica artículos en español sobre Infectología latinoamericana. Los propósitos de nuestra revista son: Difundir la experiencia nacional y latinoamericana en la especialidad Divulgar la doctrina de la Sociedad Chilena de Infectología (SOCHINF) sobre el adecuado uso de los recursos diagnósticos, terapéuticos y preventivos de infecciones. Las temáticas que cubre la revista son: Antimicrobianos Epidemiología de Infecciones Infecciones de la Comunidad o Asociadas a la Atención de Salud Infecciones en Hospederos Inmunocomprometidos Microbiología Parasitología Patogénesis VIH Vacunas.