Angiotensin II Type 1 Receptor Antibodies Are Higher in Lupus Nephritis and Vasculitis than Other Glomerulonephritis Patients

IF 2.9 4区 医学 Q3 IMMUNOLOGY
Maciej Szymczak, Harald Heidecke, Marcelina Żabińska, Dagna Rukasz, Krzysztof Wiśnicki, Andrzej Tukiendorf, Magdalena Krajewska, Mirosław Banasik
{"title":"Angiotensin II Type 1 Receptor Antibodies Are Higher in Lupus Nephritis and Vasculitis than Other Glomerulonephritis Patients","authors":"Maciej Szymczak,&nbsp;Harald Heidecke,&nbsp;Marcelina Żabińska,&nbsp;Dagna Rukasz,&nbsp;Krzysztof Wiśnicki,&nbsp;Andrzej Tukiendorf,&nbsp;Magdalena Krajewska,&nbsp;Mirosław Banasik","doi":"10.1007/s00005-022-00660-x","DOIUrl":null,"url":null,"abstract":"<div><p>Angiotensin II type 1 receptor (AT1R) antibodies are considered non-HLA (human leukocyte antigen) antibodies connected with humoral rejection after kidney transplantation. The role of AT1R antibodies in the pathogenesis of glomerular diseases and systemic vasculitis is unknown. We assessed the level of AT1R antibodies in 136 patients with different types of glomerulonephritis and systemic vasculitis and we observed kidney function and proteinuria, serum albumin and total protein levels for 2 years. The mean levels of AT1R antibodies were the following: 6.00 ± 1.31 U/ml in patients with membranous nephropathy (<i>n</i> = 18), 5.67 ± 1.31 U/ml with focal and segmental glomerulosclerosis (<i>n</i> = 25), 6.26 ± 2.25 U/ml with lupus nephropathy (<i>n</i> = 17), 10.60 ± 6.72 U/ml with IgA nephropathy (<i>n</i> = 14), 6.69 ± 2.52 U/ml with mesangial proliferative (non IgA) glomerulonephritis (<i>n</i> = 6), 6.63 ± 1.38 U/ml with systemic vasculitis (<i>n</i> = 56), including c-ANCA (anti-neutrophil cytoplasmic antibodies) vasculitis: 11.22 ± 10.78 U/ml (<i>n</i> = 40) and p-ANCA vasculitis: 12.65 ± 14.59 U/ml (<i>n</i> = 16). The mean AT1R antibodies level was higher in patients with lupus nephropathy and systemic vasculitis compared to glomerulonephritis groups. An inverse statistically significant correlation between AT1R antibodies and serum albumin (<i>r</i> =  − 0.51) in membranous nephropathy group was also found. Prospective analysis of creatinine levels indicated an increase of creatinine levels during time among patients with higher AT1R antibodies levels in p-ANCA vasculitis. Lupus nephropathy and systemic vasculitis patients may have high levels of AT1R antibodies. AT1R antibodies may be associated with the severity of membranous nephropathy and the course of p-ANCA vasculitis, although influence of concomitant factors is difficult to exclude.</p></div>","PeriodicalId":8389,"journal":{"name":"Archivum Immunologiae et Therapiae Experimentalis","volume":"70 1","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2022-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00005-022-00660-x.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivum Immunologiae et Therapiae Experimentalis","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00005-022-00660-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Angiotensin II type 1 receptor (AT1R) antibodies are considered non-HLA (human leukocyte antigen) antibodies connected with humoral rejection after kidney transplantation. The role of AT1R antibodies in the pathogenesis of glomerular diseases and systemic vasculitis is unknown. We assessed the level of AT1R antibodies in 136 patients with different types of glomerulonephritis and systemic vasculitis and we observed kidney function and proteinuria, serum albumin and total protein levels for 2 years. The mean levels of AT1R antibodies were the following: 6.00 ± 1.31 U/ml in patients with membranous nephropathy (n = 18), 5.67 ± 1.31 U/ml with focal and segmental glomerulosclerosis (n = 25), 6.26 ± 2.25 U/ml with lupus nephropathy (n = 17), 10.60 ± 6.72 U/ml with IgA nephropathy (n = 14), 6.69 ± 2.52 U/ml with mesangial proliferative (non IgA) glomerulonephritis (n = 6), 6.63 ± 1.38 U/ml with systemic vasculitis (n = 56), including c-ANCA (anti-neutrophil cytoplasmic antibodies) vasculitis: 11.22 ± 10.78 U/ml (n = 40) and p-ANCA vasculitis: 12.65 ± 14.59 U/ml (n = 16). The mean AT1R antibodies level was higher in patients with lupus nephropathy and systemic vasculitis compared to glomerulonephritis groups. An inverse statistically significant correlation between AT1R antibodies and serum albumin (r =  − 0.51) in membranous nephropathy group was also found. Prospective analysis of creatinine levels indicated an increase of creatinine levels during time among patients with higher AT1R antibodies levels in p-ANCA vasculitis. Lupus nephropathy and systemic vasculitis patients may have high levels of AT1R antibodies. AT1R antibodies may be associated with the severity of membranous nephropathy and the course of p-ANCA vasculitis, although influence of concomitant factors is difficult to exclude.

狼疮性肾炎和血管炎患者血管紧张素II型1受体抗体高于其他肾小球肾炎患者
血管紧张素II型1受体(AT1R)抗体被认为是非hla(人白细胞抗原)抗体,与肾移植后的体液排斥反应有关。AT1R抗体在肾小球疾病和全身性血管炎发病机制中的作用尚不清楚。我们评估了136例不同类型肾小球肾炎和全身性血管炎患者的AT1R抗体水平,并观察了肾功能、蛋白尿、血清白蛋白和总蛋白水平,为期2年。AT1R抗体的平均水平以下:6.00±1.31 U /毫升膜性肾病患者(n = 18), 5.67±1.31 U /毫升焦和节段性肾小球硬化症(n = 25), 6.26±2.25 U /毫升与红斑狼疮肾病(n = 17), 10.60±6.72 U /毫升IgA肾病(n = 14), 6.69±2.52 U /毫升与系膜增生性肾小球肾炎(非IgA) (n = 6), 6.63±1.38 U /毫升与系统性血管炎(n = 56),包括c-ANCA (anti-neutrophil胞质抗体)血管炎:11.22±10.78 U /毫升(n = 40)和p-ANCA血管炎:12.65±14.59 U /毫升(n = 16)。与肾小球肾炎组相比,狼疮肾病和全身性血管炎患者的平均AT1R抗体水平更高。膜性肾病组AT1R抗体与血清白蛋白呈负相关(r = - 0.51)。肌酸酐水平的前瞻性分析表明,在p-ANCA血管炎中AT1R抗体水平较高的患者中,肌酸酐水平在一段时间内升高。狼疮肾病和全身性血管炎患者可能有高水平的AT1R抗体。AT1R抗体可能与膜性肾病的严重程度和p-ANCA血管炎的病程有关,尽管很难排除伴随因素的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信