Treatment with cefiderocol in K. pneumoniae KPC nosocomial external ventricular drainage meningitis: A brief report.

Q2 Medicine

Infezioni in Medicina Pub Date : 2022-09-01 eCollection Date: 2022-01-01 DOI:10.53854/liim-3003-15

Francesco Colombo, Ali Waheed, Sandro Panese, Claudio Scarparo, Maria Solinas, Saverio Giuseppe Parisi, Nicholas Geremia

引用次数: 5

Abstract

We report the case of successful use of cefiderocol (FDC) in a Carbapenemase Producing K. pneumoniae (CPKP) post-surgical meningitis in a 44-year-old man treated with antimicrobial therapy and external ventricular drainage (EVD). The patient was known for being colonised by CPKP; for this reason, therapy with ceftazidime/avibactam (CZA) plus fosfomycin and linezolid was started. After an initial response a CZA resistant CPKP strain was isolated from CSF culture, so the antibiotic therapy was modified to FDC with trimethoprim/sulfamethoxazole for 14 days, and EVD was replaced. A complete recovery was obtained. This is the first case report describing FDC administration in CPKP meningitis.

查看原文本刊更多论文

头孢地罗治疗肺炎克雷伯菌KPC院内外脑室引流性脑膜炎:简要报告。

我们报告一例成功使用头孢地罗(FDC)在碳青霉烯酶产生肺炎克雷伯菌(CPKP)术后脑膜炎在44岁的男性治疗抗生素治疗和心室外引流(EVD)。该患者以被CPKP定植而闻名;因此，开始使用头孢他啶/阿维巴坦(CZA)联合磷霉素和利奈唑胺治疗。初步反应后，从脑脊液培养中分离出一株CZA耐药CPKP菌株，因此将抗生素治疗改为甲氧苄啶/磺胺甲恶唑FDC治疗14天，并更换EVD。获得了完全的恢复。这是描述在CPKP脑膜炎中使用FDC的第一份病例报告。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Infezioni in Medicina Medicine-Infectious Diseases

CiteScore

8.40

自引率

0.00%

发文量

期刊介绍： The Journal publishes original papers, in Italian or in English, on topics concerning aetiopathogenesis, prevention, epidemiology, diagnosis, clinical features and therapy of infections, whose acceptance is subject to the referee’s assessment. The Journal is of interest not only to infectious disease specialists, microbiologists and pharmacologists, but also to internal medicine specialists, paediatricians, pneumologists, and to surgeons as well. The Editorial Board includes experts in each of the above mentioned fields.