Adherence to antiretroviral therapy thought package-refill among HIV+ persons at "D. Cotugno" hospital, Naples, Italy.

Q2 Medicine

Infezioni in Medicina Pub Date : 2022-09-01 eCollection Date: 2022-01-01 DOI:10.53854/liim-3003-13

Francesco Maria Fusco, Nadia Sangiovanni, Nunzia Papa, Nunzia Cuomo, Orsola Tambaro, Valentina Iodice, Vincenzo Bruner, Maria Aurora Carleo, Viviana Rizzo, Giulia Palmiero, Mariana Di Lorenzo, Micaela Spatarella, Rosaria Viglietti, Vincenzo Sangiovanni, Vincenzo Esposito

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引用次数: 0

Abstract

Background: A gold-standard for the measurement of adherence to antiretroviral therapy (ART) is lacking. Aim of this study is to verify the feasibility of a package-refill-based measurement of ART at "D. Cotugno" hospital, Naples, Italy, and the factors associated to adherence.

Methods: In the period January 2018-August 2020, we calculated the package-refill as the ratio between ART-packages actually withdrawn, and the ART packages needed to regularly take ART. Adherence was associated, trough a univariate e multivariate logistic regression, to demographical, behavioural and clinical factors.

Results: 1140 HIV+ subjects were included. At univariate logistic regression inadequate package-refill-based adherence is associated with HIV-RNA higher than 50 copies/mmL (OR 3.77-IC95% 2.76-5.13) and with HIVRNA higher than 200 copies/mmL (OR 3.98-IC95% 2.69-5.90). Being not-Italian and Injective-drug-user are associated with low adherence, having HIV/AIDS for more than 8 years is associated with better adherence.

Conclusions: Package-refill is a suitable method for measuring adherence and is associated with the condition of viral failure.

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在意大利那不勒斯"D. Cotugno"医院，艾滋病毒阳性患者坚持抗逆转录病毒治疗思想包补充。

背景:缺乏衡量抗逆转录病毒治疗(ART)依从性的金标准。本研究的目的是验证在意大利那不勒斯“D. Cotugno”医院进行的基于包装再填充的ART测量的可行性，以及与依从性相关的因素。方法:在2018年1月- 2020年8月期间，我们将补包计算为实际撤回的ART包与定期服用ART包之间的比率。通过单变量和多变量逻辑回归，依从性与人口统计学、行为和临床因素相关。结果:纳入HIV阳性受试者1140例。在单变量logistic回归中，不充分的包装再填充依从性与HIV-RNA高于50拷贝/毫升(OR 3.77-IC95% 2.76-5.13)和HIVRNA高于200拷贝/毫升(OR 3.98-IC95% 2.69-5.90)相关。非意大利人和注射吸毒者的依从性较低，感染艾滋病毒/艾滋病8年以上的依从性较好。结论:重新包装是一种合适的方法来测量粘附性，并与病毒失效的情况有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infezioni in Medicina Medicine-Infectious Diseases

CiteScore

8.40

自引率

0.00%

发文量

期刊介绍： The Journal publishes original papers, in Italian or in English, on topics concerning aetiopathogenesis, prevention, epidemiology, diagnosis, clinical features and therapy of infections, whose acceptance is subject to the referee’s assessment. The Journal is of interest not only to infectious disease specialists, microbiologists and pharmacologists, but also to internal medicine specialists, paediatricians, pneumologists, and to surgeons as well. The Editorial Board includes experts in each of the above mentioned fields.