MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in Obesity.

Frontiers in bioscience (Scholar edition) Pub Date : 2022-06-23 DOI:10.31083/j.fbs1403017

Maria Vulf, Igor Khlusov, Kristina Yurova, Natalia Todosenko, Alexandra Komar, Ivan Kozlov, Vladimir Malashchenko, Daria Shunkina, Olga Khaziakhmatova, Larisa Litvinova

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引用次数: 3

Abstract

Obesity and osteoporosis are global health problems characterized by high rates of prevalence and mortality due to complications. As people with visceral obesity age, the adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) increases, and adipocytes become the predominant stromal cells in the bone marrow microenvironment, which hinders the physiological regeneration and mineralization of bone tissue. Primary and secondary osteoporosis remain severe progressive diseases. Both osteoporosis and obesity are associated with microRNAs (miRNAs) that induce adipogenesis and osteoresorption. This review presents analyses of the roles and clinical potential of miRNAs in the epigenetic control of BMSC differentiation and the formation and function of osteoclasts in osteoporosis with and without obesity. Understanding the fine-tuned regulation of the expression of genes critical for the balance of osteogenesis/osteolysis processes may provide hope for the development of effective and safe osteoporosis therapies in the future.

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骨髓间充质干细胞在肥胖骨质疏松发生中的MicroRNA调控。

肥胖和骨质疏松症是全球性的健康问题，其特点是发病率和并发症死亡率都很高。随着肥胖者年龄的增长，骨髓间充质干细胞(BMSCs)的成脂分化增加，脂肪细胞成为骨髓微环境中占优势的基质细胞，阻碍了骨组织的生理性再生和矿化。原发性和继发性骨质疏松症仍然是严重的进行性疾病。骨质疏松和肥胖都与诱导脂肪生成和骨吸收的microRNAs (miRNAs)有关。本文综述了mirna在伴有和不伴有肥胖的骨质疏松症中BMSC分化的表观遗传控制以及破骨细胞的形成和功能中的作用和临床潜力。了解对成骨/溶骨过程平衡至关重要的基因表达的微调调控可能为未来开发有效和安全的骨质疏松症治疗提供希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Frontiers in bioscience (Scholar edition)

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