Trace element concentration and cognitive dysfunction in elderly residents in Birjand.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Current Alzheimer research Pub Date : 2022-09-13 DOI:10.2174/1567205019666220913114154

Toba Kazemi, Mitra Moodi, Shahnaz Rajabi, Farshad Sharifi, Saeed Samarghandian, Masoumeh Khorashadizadeh, Tahereh Farkhondeh

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Abstract

Trace elements were suggested to have a main role in modulating cognitive function. However, there are several controversial findings regarding the association between serum trace element concentration and cognitive function in patients with cognitive disorders. Thus, this study aimed to evaluate the changes in serum trace element concentrations in elderly with cognitive dysfunction versus the participants with normal cognitive function. This cross-sectional study included 191 older adults over 60 years from Birjand County, Iran. Participants were assessed for cognitive performance and serum trace elements concentration including aluminum (AL), cobalt (Co), cadmium (Cd), Chrome (Cr), copper (Cu), Iron (Fe), magnesium (Mg), manganese (Mn), selenium (Se) and zinc (Zn). Our findings showed no significant difference in the serum concentration of AL, Co, Cr, Zn, Fe, Mg, Mn, and Se of elderly with cognitive dysfunction versus the subjects with normal cognitive function. However, the concentration of Cu significantly increased in the serum of the elderly with cognitive dysfunction versus participants with normal function. In conclusion, our study indicated an increase in the serum concentration of Cu in the elderly with cognitive dysfunction in the sample of the Birjand Longitudinal Aging Study. However, due to the main limitations of our study including low sample size and cross-section design, these findings should be interpreted with caution.

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比尔詹德老年居民的微量元素浓度和认知功能障碍。

微量元素被认为在调节认知功能方面发挥着主要作用。然而，关于认知障碍患者血清中微量元素浓度与认知功能之间的关系，目前还存在一些争议。因此，本研究旨在评估认知功能障碍老年人与认知功能正常者血清微量元素浓度的变化。这项横断面研究包括来自伊朗比尔詹德县的 191 名 60 岁以上的老年人。研究人员对参与者的认知能力和血清微量元素浓度进行了评估，包括铝（AL）、钴（Co）、镉（Cd）、铬（Cr）、铜（Cu）、铁（Fe）、镁（Mg）、锰（Mn）、硒（Se）和锌（Zn）。我们的研究结果表明，患有认知功能障碍的老人与认知功能正常的老人相比，其血清中的AL、Co、Cr、Zn、Fe、Mg、Mn和Se的浓度没有明显差异。然而，与认知功能正常的受试者相比，认知功能障碍老年人血清中铜的浓度明显升高。总之，我们的研究表明，在比尔詹德老龄化纵向研究的样本中，认知功能障碍老年人血清中的铜浓度有所增加。然而，由于我们的研究存在样本量少和横断面设计等主要局限性，因此在解释这些发现时应谨慎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Alzheimer research 医学-神经科学

CiteScore

4.00

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.