Microbiome and Neurotrauma: Emerging Innovations.

Neurology & neurotherapy open access journal Pub Date : 2022-01-01 Epub Date: 2022-08-16
A Clark, R Zelmanovich, M R Hosseini Siyanaki, M Michel, C Hanna, C Davidson, B Lucke-Wold
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Abstract

The gut-brain axis plays an important role in bidirectional communication that exists and can be altered by injury. Neurotrauma provides acute alteration in the GI tract and alters autonomic function. In this focused review, we highlight what is known about GI disruption following neurotrauma. We then delve into how this affects recovery. Areas of innovation and emerging pre-clinical results are addressed. Finally, we address the link between neurotrauma induced GI dysfunction and progression to neurodegenerative disease states.

Abstract Image

Abstract Image

微生物组和神经创伤:新出现的创新。
肠道-大脑轴在双向交流中发挥着重要作用,这种交流存在并可因损伤而改变。神经创伤会造成消化道的急性改变,并改变自律神经功能。在这篇重点综述中,我们将重点介绍神经创伤后胃肠道功能紊乱的相关知识。然后,我们将深入探讨这对恢复的影响。我们还讨论了创新领域和新出现的临床前研究成果。最后,我们探讨了神经创伤引起的消化道功能障碍与神经退行性疾病进展之间的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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