[POLYMORPHISM OF GLUTHATIONE-S-TRANSFERASE P1 IN CHILDREN WITH REFLUX-ESOPHAGITIS].

Abstract

The distribution of allele and genotype frequencies of genes of xenobiotic detoxication (CYP2E1--PstI, RsaI, DraI; ADH, ALDH, NAT2, GSTP1, GSTM1, GSTT1) was examined in 147 patients with reflux-esophagitis (RE) and 50 conditionally healthy children 12-18 years. The frequency of AA genotype of GSTP1 gene and A allele was significantly higher in patients with RE as compared with healthy children (χ2 = 4.93; P = 0.03 and χ2 = 5.94; P = 0.01 respectively).