Role of solute carriers in response to anticancer drugs.

Molecular and cellular therapies Pub Date : 2014-05-27 eCollection Date: 2014-01-01
Qing Li, Yan Shu
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引用次数: 0

Abstract

Membrane transporters play critical roles in moving a variety of anticancer drugs across cancer cell membrane, thereby determining chemotherapy efficacy and/or toxicity. The retention of anticancer drugs in cancer cells is the result of net function of efflux and influx transporters. The ATP-binding cassette (ABC) transporters are mainly the efflux transporters expressing at cancer cells, conferring the chemo-resistance in various malignant tumors, which has been well documented over the past decades. However, the function of influx transporters, in particular the solute carriers (SLC) in cancer cells, has only been recently well recognized to have significant impact on cancer therapy. The SLC transporters not only directly bring anticancer agents into cancer cells but also serve as the uptake mediators of essential nutrients for tumor growth and survival. In this review, we concentrate on the interaction of SLC transporters with anticancer drugs and nutrients, and their impact on chemo-sensitivity or -resistance of cancer cells. The differential expression patterns of SLC transporters between normal and tumor tissues may be well utilized to achieve specific delivery of chemotherapeutic agents.

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溶质载体在抗癌药物应答中的作用。
膜转运蛋白在多种抗癌药物跨肿瘤细胞膜的移动中发挥着关键作用,从而决定化疗的疗效和/或毒性。抗癌药物在癌细胞中的滞留是外排转运体和内流转运体共同作用的结果。atp结合盒(ABC)转运体主要是在癌细胞中表达的外排转运体,在各种恶性肿瘤中具有化疗耐药性,这在过去的几十年里已经得到了很好的证明。然而,内流转运体的功能,特别是癌细胞中的溶质载体(SLC),直到最近才被充分认识到对癌症治疗有重大影响。SLC转运蛋白不仅可以直接将抗癌药物带入癌细胞,还可以作为肿瘤生长和生存所需营养物质的摄取介质。本文就SLC转运体与抗癌药物和营养物质的相互作用及其对癌细胞化学敏感性或耐药的影响进行综述。SLC转运体在正常组织和肿瘤组织之间的差异表达模式可以很好地用于实现化疗药物的特异性递送。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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