Pilot study: bone marrow stem cells as a treatment for dogs with chronic spinal cord injury.

IF 2

Regenerative Medicine Research Pub Date : 2014-12-12 eCollection Date: 2014-12-01 DOI:10.1186/2050-490X-2-9

Carlos Alberto Palmeira Sarmento, Marcio Nogueira Rodrigues, Renato Zonzini Bocabello, Andrea Maria Mess, Maria Angelica Miglino

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引用次数: 33

Abstract

Background: Chronic Spinal Cord injury is a common, severe, and medically untreatable disease. Since the functional outcomes of acute and experimental chronic spinal cord injury have been shown to improve with stem cell therapy, a case study was conducted to test if the application of stem cell also regenerates chronic SCI dysfunction. Transplantation of foetal bone marrow stem cells was applied in seven dogs with chronic spinal cord injury. Magnetic resonance images and assessments of symptoms according to the Olby scale were used to diagnose the severity of injury.

Result: All dogs improved locomotor and sensory function when examined 90 days after surgery, and showed increased movement of the hind limbs, and were able to stand upright, as well as to take small steps. Tail tone was observed in seven dogs, pain reflexes and defecation return were observed in five dogs.

Conclusion: The transplantation of bone marrow stem may be a promising, reliable and safe treatment for chronic spinal cord injury.

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初步研究:骨髓干细胞治疗犬慢性脊髓损伤。

背景:慢性脊髓损伤是一种常见的、严重的、医学上无法治愈的疾病。由于急性和实验性慢性脊髓损伤的功能结果已被证明可以通过干细胞治疗得到改善，因此我们进行了一个案例研究，以测试干细胞的应用是否也可以再生慢性脊髓功能障碍。采用胎儿骨髓干细胞移植治疗7只慢性脊髓损伤犬。采用磁共振成像和根据Olby量表评估症状来诊断损伤的严重程度。结果:术后90天检查时，所有犬的运动和感觉功能均有所改善，后肢活动增加，能够直立站立，并能小步行走。观察7只狗的尾张力，5只狗的疼痛反射和排便返回。结论:骨髓干细胞移植治疗慢性脊髓损伤是一种有前景、可靠、安全的治疗方法。

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来源期刊

Regenerative Medicine Research MEDICINE, RESEARCH & EXPERIMENTAL-

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6 weeks