Efficacy of Two Cleaning Solutions for the Decontamination of 10 Antineoplastic Agents in the Biosafety Cabinets of a Hospital Pharmacy.

Annals of Occupational Hygiene Pub Date : 2015-08-01 Epub Date: 2015-05-15 DOI:10.1093/annhyg/mev031
Marco Anastasi, Serge Rudaz, Thomas Queruau Lamerie, Pascal Odou, Pascal Bonnabry, Sandrine Fleury-Souverain
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引用次数: 24

Abstract

Objective: This study aimed to evaluate two cleaning solutions for the chemical decontamination of antineoplastic agents on the surfaces of two biosafety cabinets routinely used for chemotherapy preparation in a hospital pharmacy.

Methods: For almost 1 year (49 weeks), two different solutions were used for the weekly cleaning of two biosafety cabinets in a hospital pharmacy's centralized cytotoxic preparation unit. The solutions evaluated were a commercial solution of isopropyl alcohol (IPA) and water (70:30, vol:vol), and a detergent solution constituted by 10(-2)M of sodium dodecyl sulfate (SDS) with 20% IPA. Seven areas in each biosafety cabinet were wiped 14 times throughout the year, before and after the weekly cleaning process, according to a validated procedure. Samples were analyzed using a validated method of high-performance liquid chromatography coupled to mass spectrometry. The decontamination efficacy of these two solutions was tested for 10 antineoplastic agents: cytarabine, gemcitabine, methotrexate, etoposide phosphate, irinotecan, cyclophosphamide, ifosfamide, doxorubicin, epirubicin, and vincristine.

Results: Overall decontamination efficacies observed were 82±6% and 49±11% for SDS solution and IPA, respectively. Higher contamination levels were distributed on areas frequently touched by the pharmacy technicians-such as sleeves and airlock handles-than on scale plates, gravimetric control hardware, and work benches. Detected contaminations of cyclophosphamide, ifosfamide, gemcitabine, and cytarabine were higher than those of the others agents. SDS solution was almost 20% more efficient than IPA on eight of the antineoplastic agents.

Conclusion: Both cleaning solutions were able to reduce contamination levels in the biosafety cabinets. The efficacy of the solution containing an anionic detergent agent (SDS) was shown to be generally higher than that of IPA and, after the SDS cleaning procedure, biosafety cabinets demonstrated acceptable contamination levels.

两种清洗液对某医院药房生物安全柜内10种抗肿瘤药物的去污效果
目的:评价两种清洗液对某医院药房常用化疗制剂生物安全柜表面抗肿瘤药物的化学去污效果。方法:在近1年(49周)的时间里,采用两种不同的溶液对某医院药房集中细胞毒制剂单元的两个生物安全柜进行每周清洁。评估的溶液是异丙醇(IPA)和水(70:30,vol:vol)的商业溶液,以及由10(-2)M十二烷基硫酸钠(SDS)和20% IPA组成的洗涤剂溶液。根据一项经过验证的程序,在每周清洁过程之前和之后,每个生物安全柜的七个区域全年擦拭14次。样品采用高效液相色谱-质谱联用方法进行分析。对这两种溶液对阿糖胞苷、吉西他滨、甲氨蝶呤、磷酸依托泊苷、伊立替康、环磷酰胺、异环磷酰胺、阿霉素、表柔比星、长春新碱等10种抗肿瘤药物的去污效果进行了测试。结果:SDS溶液和IPA的总体去污率分别为82±6%和49±11%。与天平板、重量控制硬件和工作台相比,药房技术人员经常接触的地方(如袖子和气闸手柄)的污染程度更高。环磷酰胺、异环磷酰胺、吉西他滨和阿糖胞苷的检测污染高于其他药物。SDS溶液在8种抗肿瘤药物上的效率比IPA高出近20%。结论:两种清洗液均能降低生物安全柜内的污染水平。含有阴离子洗涤剂(SDS)的溶液的功效通常高于IPA,并且在SDS清洗程序之后,生物安全柜显示出可接受的污染水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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