[Radiobiological Human Tissue repository: progress and perspectives for solving the problems of radiation safety and health protection of personnel and population].

E N Kirillova, S A Romanov, C A Loffredo, M L Zakharova, V S Revina, S N Sokolova, D S Goerlitz, O V Zubkova, T V Lukianova, T I Uriadnitzkaia, O S Pavlova, U V Slukinova, A V Kolosova, K N Muksinova
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引用次数: 0

Abstract

Radiobiological Human Tissue repository was established in order to obtain and store biological material from Mayak PA workers occupationally exposed to ionizing (α- and/or γ-) radiation in a wide dose range, from the residents exposed to long term radiation due to radiation accidents and transfer of the samples to scientists for the purpose of studying the effects of radiation for people and their offspring. The accumulated biomaterial is the informational and research potential that form the basis for the work of the scientists in different spheres of biology and medicine. The repository comprises 5 sections: tumor and non-tumor tissues obtained in the course of autopsies, biopsies, surgeries, samples of blood and its components, of DNA, induced sputum, saliva, and other from people exposed or unexposed (control) to radiation. The biomaterial is stored in formalin, in paraffin blocks, slides, as well as in the freezers under low temperatures. All the information on the samples and the registrants (medical, dosimetry, demographic, and occupational data) was obtained and entered into the electronic database. A constantly updated website of the repository was developed in order to provide a possibility to get acquainted with the material and proceed with application for biosamples for scientists from Russia and abroad. Some data obtained in the course of scientific research works on the basis of the biomaterial from the Repository are briefly introduced in the review.

[放射生物学人体组织储存库:解决人员和人口辐射安全和健康保护问题的进展和前景]。
放射性生物人体组织库的建立是为了获取和储存Mayak PA工人在大剂量范围内电离(α-和/或γ-)辐射下的职业暴露的生物材料,以及由于辐射事故而长期暴露在辐射下的居民的生物材料,并将样品转移给科学家,以研究辐射对人类及其后代的影响。积累的生物材料是信息和研究潜力,构成了科学家在生物学和医学不同领域工作的基础。该储存库包括5个部分:在尸检、活检、手术过程中获得的肿瘤和非肿瘤组织、血液及其成分、DNA、诱导痰、唾液和其他来自暴露于或未暴露于(对照)辐射的人的样本。生物材料储存在福尔马林、石蜡块、载玻片中,以及低温下的冷冻箱中。获得了关于样本和登记人的所有信息(医疗、剂量学、人口统计和职业数据)并将其输入电子数据库。建立了一个不断更新的储存库网站,以便为俄罗斯和国外的科学家提供了解材料和申请生物样品的可能性。本文简要介绍了在科研工作中利用生物资源库获得的部分资料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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