[The effect of implantation of mineralized bone matrix on the regeneration of articular cartilage].

Abstract

The peculiarities of regeneration of knee articular cartilage were studied experimentally in adult Wistar rats (n = 25) using the methods of optical and electron microscopy, histochemistry and x-ray electron probe microanalysis after modeling marginal perforated defect and implantation of granulated mineralized bone matrix (MBM) into the damaged zone. This biomaterial was demonstrated to have marked chondroinductive properties, to provide prolonged activation of reparative process, accelerated organotypical remodeling and restoration of the damaged articular cartilage. The data obtained indicate the possibility of MBM application in clinical practice for the treatment of injuries and diseases of the articular cartilage.