Correlations between serum trypsinogen-2 and pancreatic cancer.

Hepato-gastroenterology Pub Date : 2015-03-01

Jianbiao Cao, Changhong Xia, Tingting Cui, Hanbin Guo, Haoran Li, Yongqiang Ren, Shuai Wang

{"title":"Correlations between serum trypsinogen-2 and pancreatic cancer.","authors":"Jianbiao Cao, Changhong Xia, Tingting Cui, Hanbin Guo, Haoran Li, Yongqiang Ren, Shuai Wang","doi":"","DOIUrl":null,"url":null,"abstract":"Background/aims: To investigate associations be- tween serum trypsinogen-2, pancreatitis and pancreatic cancer (PC) and determine cutoff values for PC diagnosis.Methodology: We recruited 88 patients from Internal Medicine/Surgical Departments of General Military Hospital of Beijing PLA between 12/2009 and 6/2010. Serum samples were collected preoperatively from 23 PC patients, 30 pancreatitis patients and 35 healthy controls. Enzyme-linked immunosorbent assay was used to detect trypsinogen-2 semiquantitatively.Results: Serum trypsinogen-2 levels of PC and pancreatitis patients were significantly higher than those of controls (51.2 ± 80.3, 107.7 ± 98.1 vs. 1.0 ± 0.5, p = 0.03, p < 0.001) and significantly higher in pancreatitis vs. PC patients (107.7 ± 98.1 vs. 51.2 ± 80.3, p = 0.01). Higher Balthazar CT grades correlated with higher trypsinogen-2 in pancreatitis group. ROC curves for trypsinogen-2 revealed optimal cutoff value 1.8 as lower PC detection limit with 95.7% sensitivity and 91.4% specificity, and optimal cutoff value 19.9 for upper PC detection limit with 87.0% sensitivity and 97.1% specificity. Trypsinogen-2 levels correlated with pancreatic injury level. An AUC of 0.73 (95% Cl: 0.59-0.84, p = 0.002) distinguished PC from pancreatitis.Conclusion: Serum trypsinogen-2 is associated with PC and pancreatitis. Levels between 1.8 μg/L and 19.9 μg/L strongly suggest PC. Detection of serum trypsinogen-2 may provide simple, sensitive, specific non-invasive initial screening for early PC diagnosis.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"435-40"},"PeriodicalIF":0.0000,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hepato-gastroenterology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background/aims: To investigate associations be- tween serum trypsinogen-2, pancreatitis and pancreatic cancer (PC) and determine cutoff values for PC diagnosis.

Methodology: We recruited 88 patients from Internal Medicine/Surgical Departments of General Military Hospital of Beijing PLA between 12/2009 and 6/2010. Serum samples were collected preoperatively from 23 PC patients, 30 pancreatitis patients and 35 healthy controls. Enzyme-linked immunosorbent assay was used to detect trypsinogen-2 semiquantitatively.

Results: Serum trypsinogen-2 levels of PC and pancreatitis patients were significantly higher than those of controls (51.2 ± 80.3, 107.7 ± 98.1 vs. 1.0 ± 0.5, p = 0.03, p < 0.001) and significantly higher in pancreatitis vs. PC patients (107.7 ± 98.1 vs. 51.2 ± 80.3, p = 0.01). Higher Balthazar CT grades correlated with higher trypsinogen-2 in pancreatitis group. ROC curves for trypsinogen-2 revealed optimal cutoff value 1.8 as lower PC detection limit with 95.7% sensitivity and 91.4% specificity, and optimal cutoff value 19.9 for upper PC detection limit with 87.0% sensitivity and 97.1% specificity. Trypsinogen-2 levels correlated with pancreatic injury level. An AUC of 0.73 (95% Cl: 0.59-0.84, p = 0.002) distinguished PC from pancreatitis.

Conclusion: Serum trypsinogen-2 is associated with PC and pancreatitis. Levels between 1.8 μg/L and 19.9 μg/L strongly suggest PC. Detection of serum trypsinogen-2 may provide simple, sensitive, specific non-invasive initial screening for early PC diagnosis.

本刊更多论文

血清胰蛋白酶原-2与胰腺癌的相关性

背景/目的:探讨血清胰蛋白酶原-2与胰腺炎和胰腺癌(PC)之间的关系，并确定诊断胰腺癌的临界值。方法:我们于2009年12月至2010年6月在北京军队总医院内科/外科招募88例患者。术前采集23例PC患者、30例胰腺炎患者和35例健康对照者的血清样本。采用酶联免疫吸附法半定量检测胰蛋白酶原-2。结果:胰腺炎患者血清胰蛋白酶原-2水平显著高于对照组(51.2±80.3、107.7±98.1∶1.0±0.5,p = 0.03, p < 0.001)，胰腺炎患者血清胰蛋白酶原-2水平显著高于对照组(107.7±98.1∶51.2±80.3,p = 0.01)。胰腺炎组Balthazar CT分级高与胰蛋白酶原-2升高相关。胰蛋白酶原-2的ROC曲线显示，最佳截断值1.8为PC的下检出限，灵敏度为95.7%，特异性为91.4%;最佳截断值19.9为PC的上检出限，灵敏度为87.0%，特异性为97.1%。胰蛋白酶原-2水平与胰腺损伤程度相关。AUC为0.73 (95% Cl: 0.59-0.84, p = 0.002)将PC与胰腺炎区分开来。结论:血清胰蛋白酶原-2与PC和胰腺炎有关。浓度在1.8 - 19.9 μg/L之间强烈提示PC。血清胰蛋白酶原-2的检测可为早期PC诊断提供简单、灵敏、特异的无创初始筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Hepato-gastroenterology 医学-外科

自引率

0.00%

发文量

审稿时长

1.9 months

期刊介绍： Hepato-Gastroenterology has been discontinued as of 2015. Extremely limited quantities of back issues in print available for sale.