[Photogenerator of trichloroacetic acid--a perspective detritylation agent for microchip oligonucleotide synthesis].

Bioorganicheskaia khimiia Pub Date : 2014-09-01
A N Siniakov, E B Nikolaenkova, I A Os'kina, V A Savel'ev, V A Samsonov, A Ia Tikhonov, M Iu Palatkina, D E Zaĭtsev
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引用次数: 0

Abstract

For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating trichloroacetic acid at radiation by light with a length of wave of 405 nanometers. [4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate has been successfully used for solid-phase oligonucleotide synthesis of desired oligonucleotides.

[三氯乙酸的光发生器——微芯片寡核苷酸合成的一种前景看好的去三烷基化剂]。
为了寻找新的去三甲基化试剂用于微阵列寡核苷酸合成,我们研究了[4-(4-甲氧基苯基)-2,6-二硝基苯基](苯基)2,2,2-三氯乙酸甲酯在寡核苷酸合成过程中4,4'-二甲氧基三甲基去三甲基化的适用性,在波长为405纳米的光辐射下生成三氯乙酸。[4-(4-甲氧基苯基)-2,6-二硝基苯基](苯基)2,2,2-三氯乙酸甲酯已成功地用于固相合成所需的寡核苷酸。
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