Michelangelo Casali, Michele Carugno, Andrea Cattaneo, Dario Consonni, Carolina Mensi, Umberto Genovese, Domenico Maria Cavallo, Anna Somigliana, Angela Cecilia Pesatori
{"title":"Asbestos Lung Burden in Necroscopic Samples from the General Population of Milan, Italy.","authors":"Michelangelo Casali, Michele Carugno, Andrea Cattaneo, Dario Consonni, Carolina Mensi, Umberto Genovese, Domenico Maria Cavallo, Anna Somigliana, Angela Cecilia Pesatori","doi":"10.1093/annhyg/mev028","DOIUrl":null,"url":null,"abstract":"<p><p>The present study analysed the asbestos lung burden in necroscopic samples from 55 subjects free from asbestos-related diseases, collected between 2009 and 2011 in Milan, Italy. Multiple lung samples were analysed by light microscopy (asbestos bodies, AB) and EDXA-scanning electron microscopy (asbestos fibres and other inorganic fibres). Asbestos fibres were detected in 35 (63.6%) subjects, with a higher frequency for amphiboles than for chrysotile. Commercial (CA) and non-commercial amphiboles (NCA) were found in roughly similar frequencies. The estimated median value was 0.11 million fibres per gram of dry lung tissue (mf g(-1)) for all asbestos, 0.09 mf g(-1) for amphiboles. In 44 (80.0%) subjects no chrysotile fibres were detected. A negative relationship between asbestos mass-weighted fibre count and year of birth (and a corresponding positive increase with age) was observed for amphiboles [-4.15%, 95% confidence interval (CI) = -5.89 to -2.37], talc (-2.12%, 95% CI = -3.94 to -0.28), and Ti-rich fibres (-3.10%, 95% CI = -5.54 to -0.60), but not for chrysotile (-2.84%, 95% CI = -7.69 to 2.27). Residential district, birthplace, and smoking habit did not affect the lung burden of asbestos or inorganic fibres. Females showed higher burden only for amphiboles (0.12 versus 0.03 mf g(-1) in males, P = 0.07) and talc fibres (0.14 versus 0 mf g(-1) in males, P = 0.03). Chrysotile fibres were shorter and thinner than amphibole fibres and NCA fibres were thicker than CA ones. The AB prevalence was 16.4% (nine subjects) with concentrations ranging from 10 to 110 AB g(-1) dry, well below the 1000 AB g(-1) threshold for establishing occupational exposure. No AB were found in subjects younger than 30 years. Our study demonstrated detectable levels of asbestos fibres in a sample taken from the general population. The significant increase with age confirmed that amphibole fibres are the most representative of cumulative exposure. </p>","PeriodicalId":8458,"journal":{"name":"Annals of Occupational Hygiene","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/annhyg/mev028","citationCount":"23","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Occupational Hygiene","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/annhyg/mev028","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2015/4/15 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 23
Abstract
The present study analysed the asbestos lung burden in necroscopic samples from 55 subjects free from asbestos-related diseases, collected between 2009 and 2011 in Milan, Italy. Multiple lung samples were analysed by light microscopy (asbestos bodies, AB) and EDXA-scanning electron microscopy (asbestos fibres and other inorganic fibres). Asbestos fibres were detected in 35 (63.6%) subjects, with a higher frequency for amphiboles than for chrysotile. Commercial (CA) and non-commercial amphiboles (NCA) were found in roughly similar frequencies. The estimated median value was 0.11 million fibres per gram of dry lung tissue (mf g(-1)) for all asbestos, 0.09 mf g(-1) for amphiboles. In 44 (80.0%) subjects no chrysotile fibres were detected. A negative relationship between asbestos mass-weighted fibre count and year of birth (and a corresponding positive increase with age) was observed for amphiboles [-4.15%, 95% confidence interval (CI) = -5.89 to -2.37], talc (-2.12%, 95% CI = -3.94 to -0.28), and Ti-rich fibres (-3.10%, 95% CI = -5.54 to -0.60), but not for chrysotile (-2.84%, 95% CI = -7.69 to 2.27). Residential district, birthplace, and smoking habit did not affect the lung burden of asbestos or inorganic fibres. Females showed higher burden only for amphiboles (0.12 versus 0.03 mf g(-1) in males, P = 0.07) and talc fibres (0.14 versus 0 mf g(-1) in males, P = 0.03). Chrysotile fibres were shorter and thinner than amphibole fibres and NCA fibres were thicker than CA ones. The AB prevalence was 16.4% (nine subjects) with concentrations ranging from 10 to 110 AB g(-1) dry, well below the 1000 AB g(-1) threshold for establishing occupational exposure. No AB were found in subjects younger than 30 years. Our study demonstrated detectable levels of asbestos fibres in a sample taken from the general population. The significant increase with age confirmed that amphibole fibres are the most representative of cumulative exposure.
本研究分析了2009年至2011年在意大利米兰收集的55名无石棉相关疾病受试者的坏死镜样本中的石棉肺负担。通过光镜(石棉体,AB)和edxa扫描电镜(石棉纤维和其他无机纤维)对多个肺样本进行分析。在35名(63.6%)受试者中检测到石棉纤维,其中角闪石比温石棉的频率更高。商业角闪石(CA)和非商业角闪石(NCA)的发现频率大致相似。所有石棉的估计中位数为每克干肺组织11万纤维(毫微克(-1)),角闪石为0.09毫微克(-1)。44例(80.0%)未检出温石棉纤维。石棉质量加权纤维数与出生年份呈负相关(并随年龄呈相应的正相关),包括角闪石[-4.15%,95%可信区间(CI) = -5.89至-2.37]、滑石粉(-2.12%,95% CI = -3.94至-0.28)和富钛纤维(-3.10%,95% CI = -5.54至-0.60),但温石棉没有(-2.84%,95% CI = -7.69至2.27)。居住地区、出生地和吸烟习惯对石棉或无机纤维的肺负荷没有影响。雌性仅对角闪石(雄性为0.12对0.03 mf g(-1), P = 0.07)和滑石粉纤维(雄性为0.14对0 mf g(-1), P = 0.03)表现出更高的负担。温石棉纤维比角闪孔纤维短且薄,NCA纤维比CA纤维厚。AB患病率为16.4%(9名受试者),浓度范围为10至110 AB g(-1)干,远低于确定职业暴露的1000 AB g(-1)阈值。30岁以下未发现AB。我们的研究表明,从一般人群中提取的样本中可检测到石棉纤维的水平。随着年龄的增长,这种显著的增加证实了角闪孔纤维是累积暴露最具代表性的。