[The dynamics of feed-forward loop depends on regulator type in indirect pathway].

Biofizika Pub Date : 2015-03-01
M A Duk, A M Samsonov, M G Samsonova
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Abstract

Gene networks contain a recurring motif, called the feed-forward loop, in which a transcription factor regulates target expression directly and indirectly via the second regulator. Here we present the results of mathematical modeling of feed-forward loops with either the transcription factor or miRNA as a repressor in the indirect pathway. We showed that the substitution of the transcription factor with miRNA changes the dynamic behavior of the feed-forward loop and lends new properties critical for biological system functioning.

[间接通路中前馈回路的动力学取决于调节器类型]。
基因网络包含一个反复出现的基序,称为前馈回路,其中一个转录因子通过第二个调节器直接或间接地调节目标表达。在这里,我们展示了在间接途径中转录因子或miRNA作为抑制因子的前馈回路的数学建模结果。我们发现用miRNA替代转录因子改变了前馈回路的动态行为,并赋予生物系统功能至关重要的新特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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