Genital herpes: oral antiviral treatments.

BMJ clinical evidence Pub Date : 2015-04-08

Lisa M Hollier, Catherine Eppes

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引用次数: 0

Abstract

Introduction: Genital herpes is an infection with herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2), and is among the most common sexually transmitted diseases.

Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of different oral antiviral treatments versus each other for a first episode of genital herpes in HIV-negative people? What are the effects of different antiviral treatments for genital herpes in HIV-positive people? We searched: Medline, Embase, The Cochrane Library, and other important databases up to October 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).

Results: We found eight studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.

Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following interventions: aciclovir, famciclovir, and valaciclovir.

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生殖器疱疹:口服抗病毒治疗。

简介:生殖器疱疹是一种1型单纯疱疹病毒(HSV-1)或2型单纯疱疹病毒(HSV-2)感染，是最常见的性传播疾病之一。方法和结果:我们进行了一项系统综述，旨在回答以下临床问题:不同的口服抗病毒治疗对hiv阴性患者首次发作生殖器疱疹的效果如何?不同的抗病毒治疗对hiv阳性患者的生殖器疱疹有什么影响?我们检索了截至2013年10月的Medline、Embase、The Cochrane Library和其他重要数据库(临床证据综述定期更新;请查看我们的网站获取最新版本的评论)。我们纳入了来自相关组织的危害警报，如美国食品和药物管理局(FDA)和英国药品和保健产品监管局(MHRA)。结果:我们发现8项研究符合我们的纳入标准。我们对干预措施的证据质量进行了GRADE评价。结论:在这篇系统综述中，我们提供了有关以下干预措施的有效性和安全性的信息:阿昔洛韦、泛环洛韦和伐昔洛韦。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BMJ clinical evidence

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