Comparison between the ASSET EZ4 NCO and Impinger Sampling Devices for Aerosol Sampling of 4,4'-Methylene Diphenyl Diisocyanate in Spray Foam Application.

Annals of Occupational Hygiene Pub Date : 2015-08-01 Epub Date: 2015-04-07 DOI:10.1093/annhyg/mev025
Silvia Puscasu, Simon Aubin, Yves Cloutier, Philippe Sarazin, Huu Van Tra, Sébastien Gagné
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引用次数: 12

Abstract

4,4'-methylene diphenyl diisocyanate (MDI) aerosol exposure evaluation in spray foam insulation application is known to be a challenge. Current available techniques are either not user-friendly or are inaccurate or are not validated for this application. A new sampler has recently been developed to address the user-friendliness issues with other samplers: the ASSET EZ4-NCO, but the use of this sampler in spray foam insulation applications has not been demonstrated or validated. Because of this, the current work was undertaken to provide a comparison of the ASSET sampler with an impinger method, considered to be the best available method in the context of spray foam insulation, and hence the pertinence of comparing this sampler to an impinger method, considered to be the best available method for measuring MDI monomer and oligomers for this particular application. Liquid chromatography coupled with tandem mass spectrometry method for MDI monomer and oligomer analysis was implemented based on the Supelco literature. It allows the analysis of MDI-dibutylamine (DBA) and MDI 3-ring-DBA with a minimum reported value of 5ng ml(-1), a dynamic range of 5-140ng ml(-1), precision <15% and accuracy >80%. This method was used to quantify MDI aerosols collected with the ASSET sampler in an MDI spray foam environment in parallel with the toluene/MOPIP impinger reference method. The ASSET sampler significantly underestimated the levels of MDI monomer and oligomers when compared to the reference method. The estimated bias was 72% (95% confidence interval [CI] 54-89%) for the monomer and 96% (95% CI 76-115%) for the oligomers. These results demonstrate the importance of evaluating each new sampler for each isocyanate application prior to a formal worker exposure evaluation.

ASSET EZ4 NCO与Impinger取样装置在喷雾泡沫应用中4,4′-亚甲基二苯基二异氰酸酯气溶胶取样的比较
4,4′-亚甲基二苯基二异氰酸酯(MDI)气溶胶暴露评估在喷雾泡沫绝缘应用中是一个挑战。当前可用的技术要么不是用户友好的,要么是不准确的,要么是没有对该应用程序进行验证。最近开发了一种新的取样器,以解决与其他取样器的用户友好性问题:ASSET EZ4-NCO,但该取样器在喷雾泡沫绝缘应用中的使用尚未得到演示或验证。正因为如此,目前的工作是将ASSET取样器与撞击法进行比较,撞击法被认为是喷射泡沫绝缘环境中最有效的方法,因此将ASSET取样器与撞击法进行比较是有针对性的,撞击法被认为是测量MDI单体和低聚物的最佳方法。在Supelco文献的基础上,采用液相色谱-串联质谱法对MDI单体和低聚物进行分析。它允许分析MDI-二丁胺(DBA)和MDI 3-环DBA,最小报告值为5ng ml(-1),动态范围为5-140ng ml(-1),精度为80%。该方法与甲苯/MOPIP撞击器参考方法并行,对ASSET取样器在MDI喷雾泡沫环境中收集的MDI气溶胶进行了定量。与参考方法相比,ASSET取样器明显低估了MDI单体和低聚物的水平。单体的估计偏倚为72%(95%置信区间[CI] 54-89%),低聚物的估计偏倚为96%(95%置信区间[CI] 76-115%)。这些结果表明,在正式的工人暴露评估之前,评估每个异氰酸盐应用的每个新采样器的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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