A model for treating HCV hepatitis in patients receiving methadone maintenance therapy.

IF 0.5 4区医学 Q4 PSYCHIATRY

Israel Journal of Psychiatry and Related Sciences Pub Date : 2014-01-01

Stephen Malnick, Victoria Sheidvasser, Alon Basevitz, Shabtai Levit

{"title":"A model for treating HCV hepatitis in patients receiving methadone maintenance therapy.","authors":"Stephen Malnick, Victoria Sheidvasser, Alon Basevitz, Shabtai Levit","doi":"","DOIUrl":null,"url":null,"abstract":"Introduction: Although hepatitis C virus (HCV) is associated with substance abuse, treatment of addicts is problematic. We report the results of a pilot scheme for treatment of HCV - infected substance abusers in a methadone maintenance center (MMC).Methods: The treatment program was carried out at a single MMC. Patients were not using illicit drugs or alcohol and received regular treatment with methadone. The program consisted of 5 stages: 1. An explanatory lecture concerning HCV (50/114 attended). 2. 25 of the 50 presented for examination including HCV RNA, genotype and viral load. 3. HCV treatment with pegylated alfa-interferon-1b and ribavarin. 4. The MMC physician and staff aided the clients' medical compliance. 5. A hepatologist (SM) volunteered his services on the basis of one 3 hourly session every 4-6 weeks, in addition to open access telephone consultation with the MMC staff physician.Results: 50 of 114 HCV seropositive clients attended the initial meeting , 25 (50%) were candidates for treatment, of whom 20 were treated. 10 had genotype 3 infection, 9 genotype 1 and 1 genotype 2. The sustained virological response (SVR) on an intention-to-treat basis was 8/20 (40%).Discussion: We present a model for the successful treatment of chronic HCV hepatitis in patients receiving methadone.","PeriodicalId":49288,"journal":{"name":"Israel Journal of Psychiatry and Related Sciences","volume":"51 4","pages":"303-5"},"PeriodicalIF":0.5000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Israel Journal of Psychiatry and Related Sciences","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Although hepatitis C virus (HCV) is associated with substance abuse, treatment of addicts is problematic. We report the results of a pilot scheme for treatment of HCV - infected substance abusers in a methadone maintenance center (MMC).

Methods: The treatment program was carried out at a single MMC. Patients were not using illicit drugs or alcohol and received regular treatment with methadone. The program consisted of 5 stages: 1. An explanatory lecture concerning HCV (50/114 attended). 2. 25 of the 50 presented for examination including HCV RNA, genotype and viral load. 3. HCV treatment with pegylated alfa-interferon-1b and ribavarin. 4. The MMC physician and staff aided the clients' medical compliance. 5. A hepatologist (SM) volunteered his services on the basis of one 3 hourly session every 4-6 weeks, in addition to open access telephone consultation with the MMC staff physician.

Results: 50 of 114 HCV seropositive clients attended the initial meeting , 25 (50%) were candidates for treatment, of whom 20 were treated. 10 had genotype 3 infection, 9 genotype 1 and 1 genotype 2. The sustained virological response (SVR) on an intention-to-treat basis was 8/20 (40%).

Discussion: We present a model for the successful treatment of chronic HCV hepatitis in patients receiving methadone.

本刊更多论文

接受美沙酮维持治疗的HCV肝炎患者的治疗模型。

虽然丙型肝炎病毒(HCV)与药物滥用有关，但成瘾者的治疗存在问题。我们报告了在美沙酮维持中心(MMC)治疗HCV感染药物滥用者的试点方案的结果。方法:治疗方案在单个MMC中进行。患者没有使用非法药物或酒精，并定期接受美沙酮治疗。该项目分为5个阶段:1.设计方案;关于丙型肝炎病毒的解释性讲座(50/114参加)。2. 其中25例接受检查，包括HCV RNA、基因型和病毒载量。3.聚乙二醇化α -干扰素-1b和利巴伐林治疗HCV。4. MMC医生和工作人员协助客户的医疗依从性。5. 一名肝病学家(SM)自愿提供服务，每4-6周进行一次3小时的会诊，此外还有与MMC主治医师的开放式电话咨询。结果:114例HCV血清阳性患者中有50例参加了初次会议，25例(50%)为治疗候选人，其中20例接受了治疗。基因3型感染10例，基因1型感染9例，基因2型感染1例。意向治疗基础上的持续病毒学反应(SVR)为8/20(40%)。讨论:我们提出了一个接受美沙酮治疗的慢性HCV肝炎患者成功治疗的模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Israel Journal of Psychiatry and Related Sciences PSYCHIATRY-

CiteScore

0.80

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： THE ISRAEL JOURNAL OF PSYCHIATRY publishes original articles dealing with the all bio-psycho-social aspects of psychiatry. While traditionally the journal has published manuscripts relating to mobility, relocation, acculturation, ethnicity, stress situations in war and peace, victimology and mental health in developing countries, papers addressing all aspects of the psychiatry including neuroscience, biological psychiatry, psychopharmacology, psychotherapy and ethics are welcome. The Editor also welcomes pertinent book reviews and correspondence. Preference is given to research reports of no more than 5,000 words not including abstract, text, references, tables and figures. There should be no more than 40 references and 4 tables or figures. Brief reports (1,500 words, 5 references) are considered if they have heuristic value. Books to be considered for review should be sent to the editorial office. Selected book reviews are invited by the editor.