Association between Apolipoprotein E Variants and Obesity-Related Traits in Mexican School Children.

Q Agricultural and Biological Sciences

Journal of Nutrigenetics and Nutrigenomics Pub Date : 2014-01-01 Epub Date: 2015-05-06 DOI:10.1159/000381345

Yanelli Rodríguez-Carmona, Marcela Pérez-Rodríguez, Eli Gámez-Valdez, Francisco J López-Alavez, Claudia I Hernández-Armenta, Norma Vega-Monter, Gerardo Leyva-García, Tulia Monge-Cázares, Daniela Barrera Valencia, Marisol Balderas Monroy, Frania Pfeffer, Guillermo Meléndez, Ana Bertha Pérez Lizaur, Jeanette Pardío, María Elizabeth Tejero

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引用次数: 6

Abstract

Background/aim: Genetic variation in apolipoprotein E (ApoE) has a key role in lipid metabolism. However, its contribution to the amount and distribution of body fat is under investigation. The aim of this study was to analyze the association between genetic variation in ApoE and obesity-related traits in Mexican school children.

Material and methods: Anthropometric, body composition and physical activity measures were conducted using standard methods in 300 children (177 girls/123 boys) who fulfilled the inclusion criteria. DNA was isolated from saliva. ApoE genotypes were analyzed by allelic discrimination. The association between variation in ApoE and anthropometric and body composition measures was investigated using the General Linear Model.

Results: The mean±SD values for age, body mass index (BMI) and waist circumference (WC) were 9.05±0.80 years, 19.01±3.83 and 67.98±10.97 cm, respectively. Approximately 46% of the participants were overweight or obese. A significant association between ApoE isoforms and WC was found after controlling for age, sex and the percentage of physical activity (p=0.025). Significant main effects were found for vigorous physical activity and light physical activity influencing the adiposity-related BMI (p<0.001) and WC (p=0.044), respectively.

Conclusions: Variation in ApoE and physical activity intensity were associated with adiposity-related phenotypes in Mexican school children.

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墨西哥学龄儿童载脂蛋白E变异与肥胖相关性状的关系

背景/目的:载脂蛋白E (ApoE)的遗传变异在脂质代谢中起关键作用。然而，它对身体脂肪的数量和分布的影响正在调查中。本研究的目的是分析墨西哥学龄儿童ApoE基因变异与肥胖相关性状之间的关系。材料与方法:采用标准方法对符合纳入标准的300名儿童(177名女孩/123名男孩)进行人体测量、身体成分和体力活动测量。从唾液中分离DNA。采用等位基因鉴别法分析ApoE基因型。ApoE变异与人体测量和身体成分测量之间的关系使用一般线性模型进行了研究。结果:年龄、体重指数(BMI)和腰围(WC)的平均值±SD分别为9.05±0.80岁、19.01±3.83和67.98±10.97 cm。大约46%的参与者超重或肥胖。在控制年龄、性别和体力活动百分比后，ApoE亚型与WC之间存在显著关联(p=0.025)。剧烈体育活动和轻度体育活动对肥胖相关BMI有显著的主要影响(结论:ApoE和体育活动强度的变化与墨西哥学龄儿童的肥胖相关表型相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrigenetics and Nutrigenomics GENETICS & HEREDITY-NUTRITION & DIETETICS

CiteScore

1.86

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.