Effect of the ADIPOQ Gene -11391G/A Polymorphism Is Modulated by Lifestyle Factors in Mexican Subjects.

Q Agricultural and Biological Sciences

Journal of Nutrigenetics and Nutrigenomics Pub Date : 2014-01-01 Epub Date: 2015-03-12 DOI:10.1159/000371801

Maritza Roxana Garcia-Garcia, María Antonieta Morales-Lanuza, Wendy Yareny Campos-Perez, Bertha Ruiz-Madrigal, Monserrat Maldonado-Gonzalez, Barbara Vizmanos, Ivan Hernandez-Cañaveral, Irinea Yañez-Sanchez, Sonia Roman, Arturo Panduro, Erika Martinez-Lopez

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引用次数: 10

Abstract

Background/aims: Single nucleotide polymorphisms (SNPs) in the ADIPOQ gene could explain the adiponectin level. However, the knowledge about the influence of genetic and lifestyle factors is not sufficient. The aim was to analyze whether the effect of the -11391G/A SNP in the ADIPOQ gene is modulated by lifestyle factors in Mexican subjects.

Methods: A cross-sectional study was performed in which 394 participants were analyzed. Genetic, anthropometric, biochemical, dietary, clinical and physical activity parameters were measured. Statistical analysis was performed with SPSSv19 software.

Results: The distribution of the -11391G/A SNP genotypes was 55.6 and 44.4% for GG and AG, respectively. The adiponectin level was modulated by the -11391G/A SNP in response to the body mass index (BMI); A allele carriers showed a higher adiponectin level compared to G homozygous carriers but only in the minor BMI tertile group (p=0.032). Adiponectin level variability was explained by gender [(r)=1.5, 95% CI 1.1-1.9, p=0.000], insulin resistance [(r)=-1.2, 95% CI -0.8 to -1.6, p=0.000], physical activity [(r)=0.6, 95% CI 0.2-0.9, p=0.002] and monounsaturated fat intake [(r)=0.5, 95% CI 0.38-1.0, p=0.047].

Conclusions: The adiponectin level was modulated by the interaction between BMI and -11391G/A SNP; this suggests that the lifestyle rather than genetic factors modulates serum adiponectin.

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墨西哥人群ADIPOQ基因-11391G/A多态性受生活方式因素调节

背景/目的:ADIPOQ基因的单核苷酸多态性(snp)可以解释脂联素水平。然而，关于遗传和生活方式因素的影响的知识是不够的。目的是分析墨西哥受试者ADIPOQ基因中-11391G/A SNP的影响是否受到生活方式因素的调节。方法:采用横断面研究方法，对394名参与者进行分析。测量了遗传、人体测量、生化、饮食、临床和身体活动参数。采用SPSSv19软件进行统计学分析。结果:-11391G/A SNP基因型在GG和AG中的分布分别为55.6%和44.4%。脂联素水平受-11391G/A SNP调节，响应于体重指数(BMI);A等位基因携带者的脂联素水平高于G纯合子携带者，但仅在BMI较小的不育组(p=0.032)。脂联素水平的变异可由性别[(r)=1.5, 95% CI 1.1-1.9, p=0.000]、胰岛素抵抗[(r)=-1.2, 95% CI -0.8 -1.6, p=0.000]、体力活动[(r)=0.6, 95% CI 0.2-0.9, p=0.002]和单不饱和脂肪摄入[(r)=0.5, 95% CI 0.38-1.0, p=0.047]来解释。结论:脂联素水平受BMI与-11391G/A SNP的相互作用调节;这表明是生活方式而不是遗传因素调节血清脂联素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrigenetics and Nutrigenomics GENETICS & HEREDITY-NUTRITION & DIETETICS

CiteScore

1.86

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.