Clonazepam needs to be taken care for refractory epilepsy: a rare case and review.

Abstract

To the Editor: Clonazepam is rarely used as a primary antiepileptic drug because of a higher incidence of side effects and potential tolerance. Here the authors report a patient whowas diagnosedwith refractory epilepsy and clonazepam was added. However, this young patient’s seizures during sleep increased due to lengthening of non-REM sleep stage 2, which is rare. The authors remind neurologists to pay attention to the distribution of ictal discharges in nocturnal polysomnography as well as the effects of antiepileptic drugs on sleep when analogous drugs are added.