The risk factors for mortality and septic shock in liver transplant recipients with ESKAPE bacteremia.

Hepato-gastroenterology Pub Date : 2015-03-01
Wen Ouyang, Xiaoxiao Li, Qiquan Wan, Qifa Ye
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引用次数: 0

Abstract

Background/aims: Although bacteremias due to the six ESKAPE pathogens have recently been identified as a serious emerging problems in solid organ transplant (SOT), no information in liver transplant recipients is available. We sought to investigate the risk factors for mortality and septic shock in liver transplant recipients with ESKAPE bacteremia.

Methodology: A retrospective analysis of bacteremia after liver transplantation was reviewed. Risk factors for mortality and septic shock caused by ESKAPE bacteremia were identified.

Results: Forty-nine episodes ofbacteremia in 37 liver transplant recipients were due to ESKAPE strains. The only factor for bacteremia-related mortality independently associated with ESKAPE was septic shock (odds ratio [OR] = 67.500, 95% confidence interval [CI] = 8.464-538.300, P < .001). The factors for septic shock independently associated with ESKAPE were white blood cells count > 15,000/mm3 (OR = 15.205, 95% CI = 2.271-101.799, P = .005) and temperature of 39 °C or greater (OR = 10.959, 95% CI = 1.592-75.450, P = .015).

Conclusions: To improve the results of liver transplantation, more effectively therapeutic treatments are of paramount importance when liver transplant recipients with ESKAPE bacteremia present with septic shock, elevated white blood cells count and high body temperature.

肝移植受者ESKAPE菌血症死亡率和感染性休克的危险因素
背景/目的:虽然六种ESKAPE病原体引起的菌血症最近被确定为实体器官移植(SOT)中一个严重的新问题,但没有关于肝移植受者的信息。我们试图调查ESKAPE菌血症肝移植受者死亡和感染性休克的危险因素。方法:回顾性分析肝移植术后菌血症。确定ESKAPE菌血症引起死亡和感染性休克的危险因素。结果:37例肝移植受者中49例菌血症由ESKAPE菌株引起。与ESKAPE独立相关的菌血症相关死亡率的唯一因素是感染性休克(优势比[OR] = 67.500, 95%可信区间[CI] = 8.464-538.300, P < .001)。脓毒性休克与ESKAPE独立相关的因素是白细胞计数> 15,000/mm3 (OR = 15.205, 95% CI = 2.271-101.799, P = 0.005)和体温39°C及以上(OR = 10.959, 95% CI = 1.592-75.450, P = 0.015)。结论:ESKAPE菌血症肝移植受者出现感染性休克、白细胞计数升高和体温升高时,更有效的治疗是提高肝移植疗效的关键。
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来源期刊
Hepato-gastroenterology
Hepato-gastroenterology 医学-外科
自引率
0.00%
发文量
1
审稿时长
1.9 months
期刊介绍: Hepato-Gastroenterology has been discontinued as of 2015. Extremely limited quantities of back issues in print available for sale.
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