Central and peripheral relationships between morphine and glucose on antinociception in rats.

Rinah T Yamamoto, Robin B Kanarek
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Abstract

Previous research from our laboratory has determined that in the absence of a gustatory response or taste hedonics, intraperitoneal (i.p.) glucose administration enhanced morphine-mediated analgesia in rats and had antinociceptive actions on its own. Two experiments examined the potential of a central mechanism for glucose's actions on morphine-mediated antinociception. Morphine (2.5 µg) was infused into the periaqueductal gray (PAG) while glucose (300 mg/kg) was injected into the peritoneal cavity, or glucose (32 nmol) was infused into the PAG while morphine (3.2 mg/kg) was injected i.p. Doses of morphine and glucose were selected based on our own prior research for being below the threshold for analgesic efficacy. Antinociception was assessed using the hot-water tail-withdrawal procedure. Tail-withdrawal latency was tested at baseline (before), and 12, 24 and 36 minutes after the i.p. injection. The results indicated that 300 mg/kg glucose, administered i.p. effectively increased the antinociceptive potency of a low dose of centrally administered morphine, while central infusion of glucose enhanced peripheral morphine-mediated antinociception. These outcomes support previous evidence of glucose's influence on the antinociception actions of opioid drugs. Furthermore, they suggest that glucose produces its enhancing actions on morphine-mediated antinociception in the brain. These results support the hypothesis that glucose does not need to go through a gustatory mechanism or taste hedonics to alter morphine's antinociceptive actions.

Abstract Image

Abstract Image

吗啡和葡萄糖对大鼠抗痛作用的中枢和外周关系
我们实验室以前的研究已经确定,在没有味觉反应或味觉享乐的情况下,腹腔注射葡萄糖可以增强吗啡介导的大鼠镇痛,而且葡萄糖本身也具有抗痛觉作用。有两项实验研究了葡萄糖对吗啡介导的镇痛作用的潜在中枢机制。在腹腔注射葡萄糖(300 毫克/千克)的同时,将吗啡(2.5 微克)注入脐周灰质(PAG);或在腹腔注射吗啡(3.2 毫克/千克)的同时,将葡萄糖(32 毫摩尔)注入脐周灰质(PAG)。抗镇痛作用是通过热水尾抽程序进行评估的。分别在基线(注射前)、注射后 12 分钟、24 分钟和 36 分钟测试缩尾潜伏期。结果表明,静脉注射 300 毫克/千克葡萄糖可有效提高小剂量吗啡的抗痛觉效力,而中枢输注葡萄糖可增强吗啡介导的外周抗痛觉作用。这些结果支持了之前关于葡萄糖影响阿片类药物抗镇痛作用的证据。此外,这些结果还表明,葡萄糖在大脑中对吗啡介导的抗痛作用产生了增强作用。这些结果支持这样的假设,即葡萄糖不需要通过味觉机制或味觉享乐来改变吗啡的抗痛觉作用。
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