Multimodality treatment by FOLFOX plus HIFU in a case of advanced pancreatic carcinoma. A case report.

IF 0.1 Q4 GASTROENTEROLOGY & HEPATOLOGY

Journal of the Pancreas Pub Date : 2015-01-31 DOI:10.6092/1590-8577/2900

Dobromir Dimitrov, Tihomir Andreev, Hyuliya Feradova, Borislav Ignatov, Kunn Zhou, Colin Johnson, Tashko Delijski, Grigor Gortchev, Slavcho Tomov

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引用次数: 13

Abstract

Context: Pancreatic cancer is one of the most aggressive malignant diseases in which the survival rate has not improved in the past 40 years.

Case report: A fifty-one-year-old male patient with inoperable metastatic pancreatic cancer and low response to chemotherapy with gemcitabine as single therapy underwent palliative high intensity focused ultrasound (HIFU) ablation. Continuing chemotherapy with folinic acid, oxaliplatin and 5-fluorouracil (FOLFOX) was made. Tools, provided by the European Organization for Research and Treatment of Cancer (EORTC) were used to evaluate his quality of life. The Global Health Status improved from 25 to 42 out of 100 and the body mass index (BMI) increased from 14.9 to 18.1 kg/m(2). Measured by the visual analog scale, the pain was reduced from 7 to 2 out of 10. Twelve months after the HIFU ablation, CT revealed decreased size of the tumor and liver lesions.

Conclusion: FOLFOX plus interventional, physical destruction of the primary tumor by HIFU sufficiently improved the quality of life, reduced pancreatic pain and provided better survival in this case.

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FOLFOX联合HIFU治疗晚期胰腺癌1例。一份病例报告。

背景:胰腺癌是最具侵袭性的恶性疾病之一，在过去的40年生存率没有提高。病例报告:一例51岁男性患者，因无法手术治疗转移性胰腺癌，对单药吉西他滨化疗反应低，接受姑息性高强度聚焦超声(HIFU)消融治疗。继续用亚叶酸、奥沙利铂和5-氟尿嘧啶(FOLFOX)化疗。使用欧洲癌症研究和治疗组织(EORTC)提供的工具来评估患者的生活质量。全球健康状况从25(满分100)提高到42(满分100)，身体质量指数(BMI)从14.9增加到18.1 kg/m(2)。通过视觉模拟评分，疼痛从7分减少到2分(满分10分)。HIFU消融12个月后，CT显示肿瘤和肝脏病变变小。结论:FOLFOX联合HIFU对原发肿瘤进行介入性物理破坏，充分改善了本病例的生活质量，减轻了胰腺疼痛，提高了生存率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of the Pancreas GASTROENTEROLOGY & HEPATOLOGY-

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