Developing a vaccine for human rhinoviruses.

Gary R McLean
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Abstract

Rhinoviruses (RV's) are common human pathogens of the respiratory tract being the most frequent cause of mild diseases of the upper respiratory tract (common cold) but more importantly they are a major initiator of acute exacerbations of chronic airway diseases. Infections can be life threatening in the latter context however RV -induced common colds have an associated economic cost from loss of productivity due to absence from work or school. There are no appropriate antiviral therapies available and vaccine strategies have failed because of the large number of viral serotypes and the lack of cross-serotype protection generated. Here, approaches past and present for development of a vaccine to these widespread human pathogens are highlighted.

Abstract Image

开发人类鼻病毒疫苗。
鼻病毒(RV's)是常见的人类呼吸道病原体,是上呼吸道轻度疾病(普通感冒)的最常见原因,但更重要的是,它们是慢性气道疾病急性加重的主要发起者。在后一种情况下,感染可能危及生命,但RV引起的普通感冒会因缺勤或缺学而造成生产力损失,从而造成相关的经济损失。由于大量的病毒血清型和缺乏产生的跨血清型保护,目前没有适当的抗病毒治疗方法,疫苗策略也失败了。这里重点介绍了过去和现在针对这些广泛存在的人类病原体开发疫苗的方法。
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