Secretion properties, clearance, and therapy in airway disease.

Translational respiratory medicine Pub Date : 2014-03-10 eCollection Date: 2014-01-01 DOI:10.1186/2213-0802-2-6
Bruce K Rubin
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引用次数: 65

Abstract

Chronic airway diseases like cystic fibrosis, chronic bronchitis, asthma, diffuse panbronchiolitis, and bronchiectasis are all associated with chronic inflammation. The airway mucosa responds to infection and inflammation in part by surface mucous (goblet) cell and submucosal gland hyperplasia and hypertrophy with mucus hypersecretion. Products of inflammation including neutrophil derived DNA and filamentous actin, effete cells, bacteria, and cell debris all contribute to mucus purulence and, when this is expectorated it is called sputum. Mucus is usually cleared by ciliary movement, and sputum is cleared by cough. These airway diseases each are associated with the production of mucus and sputum with characteristic composition, polymer structure, and biophysical properties. These properties change with the progress of the disease making it possible to use sputum analysis to identify the potential cause and severity of airway diseases. This information has also been important for the development of effective mucoactive therapy to promote airway hygiene.

Abstract Image

气道疾病的分泌特性、清除和治疗。
慢性气道疾病如囊性纤维化、慢性支气管炎、哮喘、弥漫性泛细支气管炎、支气管扩张等均与慢性炎症有关。气道黏膜对感染和炎症的部分反应是表面粘膜(杯状)细胞和粘膜下腺的增生和肥厚伴粘液分泌增多。炎症的产物,包括中性粒细胞衍生的DNA和丝状肌动蛋白、无效细胞、细菌和细胞碎片,都有助于粘液化脓,当它被咳出时,它被称为痰。粘液通常通过纤毛运动排出,痰则通过咳嗽排出。这些气道疾病都与黏液和痰液的产生有关,这些黏液和痰液具有独特的组成、聚合物结构和生物物理性质。这些特性随着疾病的进展而改变,使得利用痰液分析来确定气道疾病的潜在原因和严重程度成为可能。这一信息对于开发有效的粘膜活性疗法以促进气道卫生也很重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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