The role of the lymphatic system in rabbit models for cancer metastasis research: a perspective from comparative anatomy.

Okajimas folia anatomica Japonica Pub Date : 2014-01-01 DOI:10.2535/ofaj.91.25

Hisashi Oshiro

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引用次数: 5

Abstract

The elucidation of the pathogenesis of human diseases requires increasingly relevant and rigorous animal models. Therefore, investigators must select an appropriate mammalian model. Mice and rats are indispensable in the understanding of the mechanisms of human diseases, but other non-rodent mammals are required in certain situations. The rabbit is one such species. The rabbit exhibits greater biological similarities to humans than the mouse or rat, and the rabbit VX2 allograft cancer model has been used in a broad range of oncological studies, such as stromal responses, metastatic behaviors and therapeutic effects. Cancer cells in this model proliferate in a host rabbit that maintains a natural immunity, which makes this model attractive and unique. However, these examples constitute only a small number of advantages of a rabbit model. Numerous reports suggest that the rabbit is an attractive cancer-bearing animal model for the study of cancer metastasis and the lymphatic system. I briefly review the relevant medical literature and compare the rabbit lymphatic system with mice, rats and humans.

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淋巴系统在兔肿瘤转移模型研究中的作用:从比较解剖学的角度。

阐明人类疾病的发病机制需要越来越相关和严格的动物模型。因此，研究者必须选择合适的哺乳动物模型。小鼠和大鼠在理解人类疾病的机制中是不可或缺的，但在某些情况下也需要其他非啮齿动物。兔子就是这样一种动物。与小鼠或大鼠相比，兔表现出更大的生物学相似性，兔VX2异体移植肿瘤模型已广泛用于肿瘤研究，如基质反应、转移行为和治疗效果。该模型中的癌细胞在保持天然免疫的宿主兔子体内增殖，这使得该模型具有吸引力和独特性。然而，这些例子只构成了兔子模型的一小部分优点。许多报道表明，兔子是研究癌症转移和淋巴系统的一种有吸引力的患癌动物模型。我简要地回顾了相关的医学文献，并将兔的淋巴系统与小鼠、大鼠和人类进行了比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Okajimas folia anatomica Japonica

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