Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors

Hye-Seung Chung , Jae-Gon Kim , Jae-Won Kim , Hyung-Wook Kim , Bong-June Yoon
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引用次数: 23

Abstract

Orexin plays diverse roles in regulating behaviors, such as sleep and wake, reward processing, arousal, and stress and anxiety. The orexin system may accomplish these multiple tasks through its complex innervations throughout the brain. The emerging evidence indicates a role of orexin in emotional behaviors; however, most of the previous studies have investigated the function of orexin in naïve animals. Here, we examined a functional role of orexin in mice that had been exposed to repeated stress. Chronic social defeat stress produced differential social interaction behaviors in mice (susceptible versus resilient) and these two groups of mice displayed different levels of prepro-orexin in the hypothalamus. Exogenously added orexin A to the brain induced an antidepressant-like effect in only the susceptible mice but not in the resilient mice. In contrast, orexin A and orexin B infused together produced an anxiogenic effect in only the resilient mice and not in the susceptible mice. Furthermore, we found that the antidepressant-like effect of orexin A is mediated by the bed nucleus of the stria terminalis (BNST) after exposure to chronic restraint stress. These findings reveal a bimodal effect of the orexin system in regulating emotional behavior that depends on stress susceptibility.

给慢性应激小鼠喂食食欲素对情绪相关行为产生双峰效应
食欲素在调节行为方面发挥着多种作用,比如睡眠和清醒、奖励处理、觉醒、压力和焦虑。食欲素系统可能通过其遍布大脑的复杂神经支配来完成这些多重任务。新出现的证据表明食欲素在情绪行为中的作用;然而,大多数先前的研究都是在naïve动物中调查食欲素的功能。在这里,我们检查了食欲素在暴露于反复应激的小鼠中的功能作用。长期的社会失败压力在小鼠中产生了不同的社会互动行为(易感和弹性),这两组小鼠在下丘脑中显示出不同水平的促食欲素。在大脑中外源性添加食欲素A,只在易感小鼠中产生了类似抗抑郁的效果,而在抗抑郁小鼠中则没有。相比之下,同时注入的食欲素A和食欲素B只在有弹性的小鼠中产生焦虑效应,而在易感小鼠中则没有。此外,我们发现食欲素A的抗抑郁样作用是由慢性约束应激后的终纹床核介导的。这些发现揭示了食欲素系统在调节依赖于压力敏感性的情绪行为方面的双峰效应。
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来源期刊
Regulatory Peptides
Regulatory Peptides 医学-内分泌学与代谢
自引率
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审稿时长
2 months
期刊介绍: Regulatory Peptides provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Articles emphasizing these objectives may be based on either fundamental or clinical observations obtained through the disciplines of morphology, cytochemistry, biochemistry, physiology, pathology, pharmacology or psychology.
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