Plasma Epstein-Barr virus DNA as a biomarker for nasopharyngeal carcinoma.

Q Medicine

癌症 Pub Date : 2014-12-01 Epub Date: 2014-11-21 DOI:10.5732/cjc.014.10192

K C Allen Chan

引用次数: 56

Abstract

Nasopharyngeal carcinoma (NPC) is common in southern China and Southeast Asia. Epstein-Barr virus (EBV) infection is an important etiology for NPC, and EBV genome can be detected in almost all tumor tissues of NPC in this region. Plasma EBV DNA, when quantitatively analyzed using real-time polymerase chain reaction (PCR), has been developed as a biomarker for NPC. In this review, the different clinical applications of plasma EBV DNA in the management of NPC, including screening, monitoring, and prognostication, are discussed. In addition, the biological issues of circulating EBV DNA, including the molecular nature and clearance kinetics, are also explored.

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血浆eb病毒DNA作为鼻咽癌的生物标志物

鼻咽癌(NPC)常见于中国南部和东南亚。eb病毒(Epstein-Barr virus, EBV)感染是鼻咽癌的重要病因，在该地区鼻咽癌的几乎所有肿瘤组织中都能检测到EBV基因组。血浆EBV DNA，当使用实时聚合酶链反应(PCR)进行定量分析时，已被开发为鼻咽癌的生物标志物。本文就血浆EBV DNA在鼻咽癌筛查、监测和预后等方面的临床应用作一综述。此外，还探讨了循环EBV DNA的生物学问题，包括分子性质和清除动力学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

癌症 ONCOLOGY-

CiteScore

3.47

自引率

0.00%

发文量

9010

审稿时长

12 weeks

期刊介绍： In July 2008, Landes Bioscience and Sun Yat-sen University Cancer Center began co-publishing the international, English-language version of AI ZHENG or the Chinese Journal of Cancer (CJC). CJC publishes original research, reviews, extra views, perspectives, supplements, and spotlights in all areas of cancer research. The primary criteria for publication in CJC are originality, outstanding scientific merit, and general interest. The Editorial Board is composed of members from around the world, who will strive to maintain the highest standards for excellence in order to generate a valuable resource for an international readership.