Epstein-Barr virus and the origin of Hodgkin lymphoma.

Q Medicine

癌症 Pub Date : 2014-12-01 Epub Date: 2014-11-21 DOI:10.5732/cjc.014.10193

Martina Vockerodt, Fathima Zumla Cader, Claire Shannon-Lowe, Paul Murray

引用次数: 40

Abstract

Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.

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eb病毒和霍奇金淋巴瘤的起源

尽管eb病毒(EBV)存在于一部分经典霍奇金淋巴瘤(cHL)病例的恶性霍奇金/里德-斯滕伯格(HRS)细胞中，但该病毒如何导致这种疾病的发病机制仍不清楚。从对其他ebv相关癌症的研究中可以清楚地看出，这种病毒通常不足以导致肿瘤的发展，需要其他致癌辅助因子。本文回顾了EBV对cHL发病机制的已知贡献，并重点介绍了慢性炎症作为这种恶性肿瘤的潜在致癌辅助因素的新证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

癌症 ONCOLOGY-

CiteScore

3.47

自引率

0.00%

发文量

9010

审稿时长

12 weeks

期刊介绍： In July 2008, Landes Bioscience and Sun Yat-sen University Cancer Center began co-publishing the international, English-language version of AI ZHENG or the Chinese Journal of Cancer (CJC). CJC publishes original research, reviews, extra views, perspectives, supplements, and spotlights in all areas of cancer research. The primary criteria for publication in CJC are originality, outstanding scientific merit, and general interest. The Editorial Board is composed of members from around the world, who will strive to maintain the highest standards for excellence in order to generate a valuable resource for an international readership.