Cutaneous mastocytosis combined with eruptive melanocytic nevi and melanoma. Coincidence or a linkage in the pathogenesis?

Journal of dermatological case reports Pub Date : 2014-09-30 DOI:10.3315/jdcr.2014.1179

Pietro Donati, Giovanni Paolino, Michele Donati, Chiara Panetta

{"title":"Cutaneous mastocytosis combined with eruptive melanocytic nevi and melanoma. Coincidence or a linkage in the pathogenesis?","authors":"Pietro Donati, Giovanni Paolino, Michele Donati, Chiara Panetta","doi":"10.3315/jdcr.2014.1179","DOIUrl":null,"url":null,"abstract":"Background: Cellular combinations in the same neoplasm can have intriguing physiopathological implications, which may be useful to better understand the biology of the diseases.Main observations: Urticaria pigmentosa in association with eruptive melanocytic nevi was observed in a female patient. Maculopapular lesions extended at the base of different melanocytic nevi and the histopathological examination revealed the presence of a mast cell population in the papillary and reticular dermis combined with overlying melanocytic nevi. The re-evaluation of a melanoma removed three years before revealed the presence of the same pathological features. Immunohistochemical assays showed a strong positivity to Giemsa, Toluidine blue and CD-117 in the mast cells, while a S-100 reaction was observed in the melanocytic population.Conclusions: We discuss possible pathogenetic linkage between cutaneous mastocytosis and melanoma.","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"8 3","pages":"70-4"},"PeriodicalIF":0.0000,"publicationDate":"2014-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3315/jdcr.2014.1179","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of dermatological case reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3315/jdcr.2014.1179","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 15

Abstract

Background: Cellular combinations in the same neoplasm can have intriguing physiopathological implications, which may be useful to better understand the biology of the diseases.

Main observations: Urticaria pigmentosa in association with eruptive melanocytic nevi was observed in a female patient. Maculopapular lesions extended at the base of different melanocytic nevi and the histopathological examination revealed the presence of a mast cell population in the papillary and reticular dermis combined with overlying melanocytic nevi. The re-evaluation of a melanoma removed three years before revealed the presence of the same pathological features. Immunohistochemical assays showed a strong positivity to Giemsa, Toluidine blue and CD-117 in the mast cells, while a S-100 reaction was observed in the melanocytic population.

Conclusions: We discuss possible pathogenetic linkage between cutaneous mastocytosis and melanoma.

Abstract Image

查看原文本刊更多论文

皮肤肥大细胞增多症合并发疹性黑素细胞痣和黑色素瘤。发病机制上的巧合还是联系?

背景:同一肿瘤中的细胞组合可能具有有趣的生理病理意义，这可能有助于更好地了解疾病的生物学。主要观察:在一位女性患者中观察到与爆发性黑素细胞痣相关的色素性荨麻疹。斑疹丘疹病变延伸到不同黑素细胞痣的基部，组织病理学检查显示乳头状和网状真皮中存在肥大细胞群，并覆盖黑素细胞痣。对三年前切除的黑色素瘤的重新评估显示存在相同的病理特征。免疫组化检测显示肥大细胞对吉姆萨、甲苯胺蓝和CD-117呈强阳性，黑素细胞群呈S-100反应。结论:我们讨论皮肤肥大细胞增多症和黑色素瘤之间可能的发病联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of dermatological case reports

自引率

0.00%

发文量