Association of Age at Menarche and Menstrual Characteristics with Adult Onset Asthma among Reproductive Age Women.

Neway G Fida, Michelle A Williams, Daniel A Enquobahrie
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Abstract

Background: Observations of increasing asthma incidence, decreasing age at menarche, and common risk factors have led investigators to hypothesize potential associations of age at menarche or menstrual characteristics with incidence of adult onset asthma. We evaluated these associations among reproductive age women.

Methods: Study participants were selected from among women enrolled in a pregnancy cohort study. Information on age at menarche, menstrual characteristics, and history of asthma was collected using interviewer-administered questionnaires. Adult onset asthma was defined as asthma first diagnosed after onset of menarche. Women who had no information on asthma and menstrual history and those who were diagnosed with asthma before menarche were excluded. A total of 3,461 women comprised the analytic population. Logistic regression was used to estimate adjusted relative risk (aRR) and 95% confidence intervals (95% CI) relating age at menarche and menstrual characteristics with adult onset asthma.

Results: Mean age at menarche was 12.8 years (standard deviation=1.46). Among study participants, 7.5% were diagnosed with asthma after the onset of menarche. After controlling for potential confounders (age, race, body mass index, and socio-economic status), women who had early menarche (<12 years old) had 60% higher risk of being diagnosed with adult onset asthma as compared with women who did not have early menarche (≥ 12 years old) (aRR= 1.59, 95% CI 1.19 - 2.13). Menstrual irregularities or abnormal (short or long) cycle length were not associated with risk of adult onset asthma. In addition, no significant interaction was observed between age at menarche or menstrual characteristics with body mass index or physical activity (in adolescence) in relation to adult onset asthma.

Conclusion: Early menarche is associated with a higher risk of developing adult onset asthma among reproductive age women. Mechanisms for this association are potential areas of future research.

初潮年龄和月经特征与育龄妇女成年后哮喘的关系。
背景:哮喘发病率的增加、月经初潮年龄的降低以及常见的风险因素导致研究人员假设月经初潮年龄或月经特征与成人哮喘发病率可能存在关联。我们对育龄妇女的这些关联进行了评估:方法:我们从参加妊娠队列研究的妇女中选取了研究对象。研究人员通过访谈问卷收集了有关初潮年龄、月经特征和哮喘病史的信息。成人哮喘的定义是月经初潮后首次诊断出的哮喘。没有提供哮喘和月经史资料的妇女以及在月经初潮前被诊断患有哮喘的妇女被排除在外。分析人群中共有 3461 名女性。采用逻辑回归法估算了月经初潮年龄和月经特征与成年哮喘发病的调整相对风险(aRR)和 95% 置信区间(95% CI):月经初潮的平均年龄为 12.8 岁(标准差=1.46)。在研究参与者中,7.5%的人在初潮后被诊断出患有哮喘。在对潜在的混杂因素(年龄、种族、体重指数和社会经济地位)进行控制后,初潮过早的女性(结论:初潮过早与哮喘的发生有关:初潮过早与育龄妇女罹患成人哮喘的风险较高有关。这种关联的机制是未来研究的潜在领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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