{"title":"Molecular Imaging Using Endogenous Cellular Proteins.","authors":"Zhou Jinyuan, Hong Xiaohua","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Amide proton transfer (APT) imaging is a novel molecular MRI technique that generates image contrast based on endogenous cellular proteins in tissue. Theoretically, the APT-MRI signal depends primarily on the mobile amide proton concentration and amide proton exchange rates (which are related to tissue pH). The APT technique has been used for non-invasive pH imaging in stroke (where pH drops) and protein content imaging in tumor (where many proteins are overexpressed). Notably, it has been recently demonstrated in animal models that the APT-MRI signal is a unique imaging biomarker to distinguish between radiation necrosis and active tumor. In this paper, we will briefly introduce the basic principle of APT imaging and review its current successful applications for the imaging of stroke and the imaging of brain tumors in animal models and in patients.</p>","PeriodicalId":10063,"journal":{"name":"波谱学杂志","volume":"30 3","pages":"307-321"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176899/pdf/nihms-441495.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"波谱学杂志","FirstCategoryId":"1089","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Amide proton transfer (APT) imaging is a novel molecular MRI technique that generates image contrast based on endogenous cellular proteins in tissue. Theoretically, the APT-MRI signal depends primarily on the mobile amide proton concentration and amide proton exchange rates (which are related to tissue pH). The APT technique has been used for non-invasive pH imaging in stroke (where pH drops) and protein content imaging in tumor (where many proteins are overexpressed). Notably, it has been recently demonstrated in animal models that the APT-MRI signal is a unique imaging biomarker to distinguish between radiation necrosis and active tumor. In this paper, we will briefly introduce the basic principle of APT imaging and review its current successful applications for the imaging of stroke and the imaging of brain tumors in animal models and in patients.
期刊介绍：
'BOPUXUE ZAZHI' (Chinese Journal of Magnetic Resonance, Abbreviation: Chinese J Magn Reson), is the official journal of the Committee of Magnetic Resonance of the Chinese Physics Society, and sponsored by Innovation Academy for Precision Measurement Science and Technology, CAS. It is a Chinese journal dedicated to magnetic resonance community and distributed publicly at home and abroad.
The journal covers all areas of magnetic resonance, and interaction of atoms with microwave field, including high resolution liquid and solid state nuclear magnetic resonance (NMR); in vivo magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and functional magnetic resonance imaging (fMRI); electron spin/paramagnetic resonance (ESR); nuclear quadruple resonance (NQR); laser magnetic resonance (LMR); atomic frequency standards etc.
The journal seeks the papers about novel, new and significant developments in the physical principles underlying all these spectroscopies, and methodologies and applications of magnetic resonance in chemistry, biology, medicine, geochemistry, ecology, and related fields. The journal provides an international forum for mini-reviews and communications which merit urgent publication. Four high-quality and breakthrough categories of contribution are presented: Full papers, Research Notes, Rapid communications and Review articles.
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