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{"title":"Human epidermal neural crest stem cells as candidates for cell-based therapies, disease modeling, and drug discovery","authors":"Maya Sieber-Blum","doi":"10.1002/bdrc.21073","DOIUrl":null,"url":null,"abstract":"<p>In this review article I explore the suitability of human epidermal neural crest stem cells (hEPI-NCSC) for translational medicine. hEPI-NCSC are multipotent somatic stem cells that are derived from the embryonic neural crest. hEPI-NCSC are located in the bulge of hair follicles where they persist postnatally and into adulthood. Because of their location in the hairy skin and their migratory behavior, hEPI-NCSC can be easily isolated as a highly pure population of stem cells without the need for purification. Furthermore they can be expanded ex vivo into millions of stem cells, they do not form tumors in vivo, and they can undergo directed differentiation into crest and noncrest-derived cell types of clinical relevance. Taken together, these characteristics make hEPI-NCSC attractive candidates for cell-based therapies, drug discovery, and disease modeling. Birth Defects Research (Part C) 102:221–226, 2014. © 2014 Wiley Periodicals, Inc.</p>","PeriodicalId":55352,"journal":{"name":"Birth Defects Research Part C-Embryo Today-Reviews","volume":"102 3","pages":"221-226"},"PeriodicalIF":0.0000,"publicationDate":"2014-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/bdrc.21073","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Birth Defects Research Part C-Embryo Today-Reviews","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bdrc.21073","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 10
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Abstract
In this review article I explore the suitability of human epidermal neural crest stem cells (hEPI-NCSC) for translational medicine. hEPI-NCSC are multipotent somatic stem cells that are derived from the embryonic neural crest. hEPI-NCSC are located in the bulge of hair follicles where they persist postnatally and into adulthood. Because of their location in the hairy skin and their migratory behavior, hEPI-NCSC can be easily isolated as a highly pure population of stem cells without the need for purification. Furthermore they can be expanded ex vivo into millions of stem cells, they do not form tumors in vivo, and they can undergo directed differentiation into crest and noncrest-derived cell types of clinical relevance. Taken together, these characteristics make hEPI-NCSC attractive candidates for cell-based therapies, drug discovery, and disease modeling. Birth Defects Research (Part C) 102:221–226, 2014. © 2014 Wiley Periodicals, Inc.
人类表皮神经嵴干细胞作为细胞治疗、疾病建模和药物发现的候选细胞
在这篇综述文章中，我探讨了人表皮神经嵴干细胞(hEPI-NCSC)在转化医学中的适用性。hEPI-NCSC是来源于胚胎神经嵴的多能体细胞干细胞。hEPI-NCSC位于毛囊的凸起处，它们在出生后持续存在并进入成年期。由于hEPI-NCSC位于多毛皮肤中，并且具有迁移行为，因此可以很容易地分离出高纯度的干细胞群，而无需纯化。此外，它们可以在体外扩增成数百万个干细胞，在体内不会形成肿瘤，并且可以直接分化为具有临床意义的嵴和非嵴来源的细胞类型。综上所述，这些特征使hEPI-NCSC成为基于细胞的治疗、药物发现和疾病建模的有吸引力的候选者。出生缺陷研究(C辑)(2):221 - 226,2014。©2014 Wiley期刊公司
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