[Host-pathogen interaction of Legionella pneumophila].

Hiroki Nagai
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Abstract

Legionella are gram-negative bacteria ubiquitously found in freshwater and soil environments. Once inhaled by humans, Legionella infection could result in a severe form of pneumonia known as Legionellosis. Legionella translocate ~300 effector proteins into host cells via the Dot/Icm type IV secretion system, which is central to Legionella pathogenesis. Here I describe a brief review on recent advances in research on the molecular basis of Legionella-eukaryotic-cell interaction.

[嗜肺军团菌的宿主-病原体相互作用]。
军团菌是在淡水和土壤环境中普遍存在的革兰氏阴性细菌。一旦被人类吸入,军团菌感染可能导致一种被称为军团菌病的严重肺炎。军团菌通过Dot/Icm IV型分泌系统将约300种效应蛋白转运到宿主细胞中,这是军团菌发病的核心。本文就军团菌与真核细胞相互作用的分子基础的最新研究进展作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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